ArticleBrain structure & function2017
Magnetic resonance diffusion tensor imaging for the pedunculopontine nucleus: proof of concept and histological correlation.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson's Disease.Journal of Parkinson's disease · 2023Trial
- A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease-related neuropathology.Brain pathology (Zurich, Switzerland) · 2026Article
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
- Effects of levodopa on motor and cerebellar network connectivity in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- LRRK2 mutation contributes to decreased free water in the nucleus basalis of Meynert in manifest and premanifest Parkinson's disease.Journal of neurology · 2024Article
- A roadmap towards standardized neuroimaging approaches for human thalamic nuclei.Nature reviews. Neuroscience · 2024Review
- Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers.NPJ Parkinson's disease · 2024Article
- Mixed methodology in human brain research: integrating MRI and histology.Brain structure & function · 2023Review
- Direct localization and delineation of human pedunculopontine nucleus based on a self-supervised magnetic resonance image super-resolution method.Human brain mapping · 2023Article
- Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease.Brain : a journal of neurology · 2023Article
- Structural and functional changes of the cerebellum in temporal lobe epilepsy.Frontiers in neurology · 2023Article
- A unified 3D map of microscopic architecture and MRI of the human brain.Science advances · 2022Article
- Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation.NeuroImage · 2022Article
- Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- Pedunculopontine Nucleus Dysconnectivity Correlates With Gait Impairment in Parkinson's Disease: An Exploratory Study.Frontiers in aging neuroscience · 2022Article
- Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- New Developments in Cholinergic Imaging in Alzheimer and Lewy Body Disorders.Current behavioral neuroscience reports · 2020Article
- Anatomical Characterization of the Human Structural Connectivity between the Pedunculopontine Nucleus and Globus Pallidus via Multi-Shell Multi-Tissue Tractography.Medicina (Kaunas, Lithuania) · 2020Article
- A multimodal computational pipeline for 3D histology of the human brain.Scientific reports · 2020Article
- 7 Tesla MRI Followed by Histological 3D Reconstructions in Whole-Brain Specimens.Frontiers in neuroanatomy · 2020Article
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Authors and funding
17 authors at 5 institutions in 4 countries.
Funding
Abstract
The pedunculopontine nucleus (PPN) has been proposed as target for deep brain stimulation (DBS) in patients with postural instability and gait disorders due to its involvement in muscle tonus adjustments and control of locomotion. However, it is a deep-seated brainstem nucleus without clear imaging or electrophysiological markers. Some studies suggested that diffusion tensor imaging (DTI) may help guiding electrode placement in the PPN by showing the surrounding fiber bundles, but none have provided a direct histological correlation. We investigated DTI fractional anisotropy (FA) maps from in vivo and in situ post-mortem magnetic resonance images (MRI) compared to histological evaluations for improving PPN targeting in humans. A post-mortem brain was scanned in a clinical 3T MR system in situ. Thereafter, the brain was processed with a special method ideally suited for cytoarchitectonic analyses. Also, nine volunteers had in vivo brain scanning using the same MRI protocol. Images from volunteers were compared to those obtained in the post-mortem study. FA values of the volunteers were obtained from PPN, inferior colliculus, cerebellar crossing fibers and medial lemniscus using histological data and atlas information. FA values in the PPN were significantly lower than in the surrounding white matter region and higher than in areas with predominantly gray matter. In Nissl-stained histologic sections, the PPN extended for more than 10 mm in the rostro-caudal axis being closely attached to the lateral parabrachial nucleus. Our DTI analyses and the spatial correlation with histological findings proposed a location for PPN that matched the position assigned to this nucleus in the literature. Coregistration of neuroimaging and cytoarchitectonic features can add value to help establishing functional architectonics of the PPN and facilitate neurosurgical targeting of this extended nucleus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.