Trial reportClinical research in cardiology : official journal of the German Cardiac Society2017
Predictors for permanent pacemaker implantation in patients undergoing transfemoral aortic valve implantation with the Edwards Sapien 3 valve.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Coronary and Structural Interventions - Transcatheter Aortic Valve Replacement
Edwards SAPIEN 3 PPI Registry - A Retrospective Survey and Prospective Identification of Procedure Related Variables Associated With Permanent Pacemaker Implantation in Patients Receiving an Edwards SAPIEN 3 Valve
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Do Women Require Less Permanent Pacemaker After Transcatheter Aortic Valve Implantation? A Meta-Analysis and Meta-Regression.Journal of the American Heart Association · 2021Pooled it
- Modifiable risk factors for permanent pacemaker after transcatheter aortic valve implantation: CONDUCT registry.Open heart · 2023Trial
- Article
- Aortic Valve and Left Ventricular Outflow Tract Calcium Distribution and Conduction Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Structural heart : the journal of the Heart Team · 2025Review
- Single-Centre Experience with the Balloon-Expandable Myval Transcatheter Aortic Valve System with the First 200 Patients: 30-Day and 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- [Left bundle branch pacing in a patient with decreased cardiac function after transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Article
- Real-world procedural and clinical outcomes of contemporary balloon-expandable and self-expandable TAVR systems: a single-center experience.Frontiers in cardiovascular medicine · 2025Article
- Predictors, clinical impact, and management strategies for conduction abnormalities after transcatheter aortic valve replacement: an updated review.Frontiers in cardiovascular medicine · 2024Review
- Association of CT-Derived Extracardiac Features and Aortic Annulus Size in Patients Planned for TAVI.Journal of personalized medicine · 2023Article
- Unmet Needs in TAVR: Conduction Disturbances and Management of Coronary Artery Disease.Journal of clinical medicine · 2022Review
- 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- [Influence of deep implantation on conduction disturbances after transcatheter aortic valve implantation].Herzschrittmachertherapie & Elektrophysiologie · 2021Article
- Impact of Bundle Branch Block on Permanent Pacemaker Implantation after Transcatheter Aortic Valve Implantation: A Meta-Analysis.Journal of clinical medicine · 2021Article
- Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis.Heart and vessels · 2020Article
- Expansion of TAVR into Low-Risk Patients and Who to Consider for SAVR.Cardiology and therapy · 2020Review
- The incidence and impact of cardiac conduction disturbances after transcatheter aortic valve replacement.Annals of cardiothoracic surgery · 2020Review
- Overcoming the transcatheter aortic valve replacement Achilles heel: conduction abnormalities-a systematic review.Annals of cardiothoracic surgery · 2020Article
- Transvascular transcatheter aortic valve implantation in 2017.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Evaluating the Validity of Risk Scoring in Predicting Pacemaker Rates following Transcatheter Aortic Valve Replacement.Journal of interventional cardiology · 2020Article
- One year VARC-2-defined clinical outcomes after transcatheter aortic valve implantation with the SAPIEN 3.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPredictors for the need of permanent pacemaker implantation (PPMI) in the context of transcatheter aortic valve implantation (TAVI) are not well defined yet. We evaluated the impact of conduction disturbances, calcium volume of the device landing zone, oversizing and implantation depth on PPMI after TAVI with the balloon-expandable Edwards Sapien 3 (ES3). METHODS AND
results335 consecutive patients undergoing transfemoral TAVI with the ES3 for the treatment of symptomatic severe aortic stenosis were included (clinicaltrials NCT02162069). Rate of PPMI after TAVI was 18.4%, excluding patients with permanent pacemakers prior to TAVI or valve-in-valve implantations. Patients requiring PPMI more often had first degree atrioventricular block (AVB) at baseline (48.7 vs. 16.5%, p < 0.01), preprocedural complete right bundle branch block (RBBB; 25.0 vs. 3.9%, p < 0.01) and higher calcium volume of the aortic valve (258.5 ± 317.3 vs. 163.6 ± 178.8 mm³, p < 0.01). There was a trend towards higher rate of PPMI in patients with new-onset left bundle branch block after TAVI (32.7 vs. 20.7%, p = 0.06). Multivariate logistic regression analysis showed that baseline first degree AVB (odds ratio 3.9, 95% confidence interval 1.73-9.10, p < 0.01) and preprocedural complete RBBB (odds ratio 4.5, 95% confidence interval 1.50-13.21, p < 0.01) were independent predictors of PPMI. Of note, neither oversizing nor implantation depth were independent predictors for need of PPMI with the ES3.
conclusionsIn patients treated with the ES3 for symptomatic severe aortic stenosis first degree AVB and complete RBBB at baseline were independently associated with higher rates of postprocedural PPMI, whereas implantation depth and oversizing did not have an impact on PPMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.