ArticleCancer research2017
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Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Comprehensive evidence for the pathogenicity of theJournal of medical genetics · 2026Article
- Prevalence of germline 113 cancer genes in healthy Indonesian hospital staff.Genes & genomics · 2026Article
- Clinical variant interpretation comparing two saturation genome editing-based functional studies forFrontiers in genetics · 2026Article
- A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription.Nature communications · 2025Article
- Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions.Nature communications · 2025Article
- Understanding the genetic epidemiology of hereditary breast cancer in India using whole genome data from 1029 healthy individuals.Cancer causes & control : CCC · 2025Article
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- Reduced penetrance BRCA1 and BRCA2 pathogenic variants in clinical germline genetic testing.NPJ precision oncology · 2024Article
- The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.Nucleic acids research · 2024Article
- Clinical impact of panel gene sequencing on therapy of advanced cancers of the digestive system: a retrospective, single center study.BMC cancer · 2024Article
- Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells.Nature biomedical engineering · 2024Article
- Functional evaluation of BRCA1/2 variants of unknown significance with homologous recombination assay and integrative in silico prediction model.Journal of human genetics · 2023Article
- Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.Cell death & disease · 2023Article
- Replication gap suppression depends on the double-strand DNA binding activity of BRCA2.Nature communications · 2023Article
- Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer.Annals of surgical oncology · 2022Review
- Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.Oncogene · 2022Article
- The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus.Frontiers in genetics · 2022Article
- Homologous Recombination Deficiency in Ovarian, Breast, Colorectal, Pancreatic, Non-Small Cell Lung and Prostate Cancers, and the Mechanisms of Resistance to PARP Inhibitors.Frontiers in oncology · 2022Review
- The Impact of Mediterranean Dietary Intervention on Metabolic and Hormonal Parameters According toFrontiers in genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
135 authors.
Hermela ShimelisDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Romy L S MesmanDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Catharina Von NicolaiGenotoxic Stress and Cancer, Institut Curie, Orsay, France.
Asa EhlenGenotoxic Stress and Cancer, Institut Curie, Orsay, France.
Lucia GuidugliDepartment of Human Genetics, University of Chicago, Chicago, Illinois.
Charlotte MartinResearch Center, Institute Curie, Orsay, France.
Fabienne M G R CalléjaDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Huong MeeksCancer Control and Population Sciences, University of Utah, Salt Lake City, Utah.
Emily HallbergDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Jamie HintonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Jenna LilyquistDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Chunling HuDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Cora M AalfsDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Irene AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, California.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias W BeckmannDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Javier BenitezHuman Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.
Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Stig E BojesenCopenhagen General Population Study, Herlevand Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Manjeet K BollaDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Anne-Lise Borresen-DaleDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Annegien BroeksNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Barbara BrouwersLaboratory of Experimental Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium.
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Georgia Chenevix-Trench
Ching-Yu ChengSingapore Eye Research Institute, National University of Singapore, Singapore, Singapore.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
J Margriet ColléeDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Angela CoxSheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Joe DennisDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Isabel Dos-Santos-SilvaDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Alison M DunningDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Peter A FaschingDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Jonine FigueroaUsher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, United Kingdom.
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Gord GlendonLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Pascal GuénelCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Frans B HogervorstNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Antoinette HollestelleDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Daehee KangDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Veli-Matti KosmaCancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Vessela Kristensen
Kah-Nyin LaiCancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia.
Diether LambrechtsVesalius Research Center, Leuven, Belgium.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Artitaya LophatananonDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, United Kingdom.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Eva MachackovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Arto MannermaaCancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Sara MargolinDepartment of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
Frederik MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Keitaro MatsuoDepartment of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hui MiaoSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Kyriaki MichailidouDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Kenneth MuirDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, United Kingdom.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Curtis OlswoldDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Jan J C OosterwijkDepartment of Genetics, University of Groningen, Groningen, the Netherlands.
Ana OsorioHuman Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.
Paolo PeterlongoIFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
Muhammad Usman RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Valerie RheniusDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Suleeporn SangrajrangNational Cancer Institute, Bangkok, Thailand.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London, United Kingdom.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Caroline SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Mitul ShahDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Chen-Yang ShenSchool of Public Health, China Medical University, Taichung, Taiwan.
Martha ShrubsoleDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, Australia.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Anthony SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Soo H TeoCancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thérèse TruongCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Lizet E van der KolkNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Qin WangDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Jyh-Cherng YuDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Jennifer LearyWestmead Millenium Institute for Medical Research, University of Sydney, Sydney, Australia.
Logan WalkerDepartment of Pathology, University of Otago, Christchurch, New Zealand.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Florentia FostiraMolecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), Athens, Greece.
Kathleen B M ClaesCenter for Medical Genetics, Ghent University Hospita, Ghent, Belgium.
Liliana VarescoUnit of Hereditary Cancers, IRCCS AOU San Martino, Genova, Italy.
Setareh MoghadasiDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Amanda SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Peter DevileeDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Harry VrielingDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Alvaro N A MonteiroCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
David E GoldgarHuntsman Cancer Institute and Department of Dermatology, University of Utah, Salt Lake City, Utah.
Aura CarreiraGenotoxic Stress and Cancer, Institut Curie, Orsay, France.
Maaike P G VreeswijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. couch.fergus@mayo.edu.
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Funding
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MEpidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4MOvarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2MRisk and penetrance of mutations from breast cancer testing panels.R01CA192393 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH, NATHANSON, KATHERINE L. · 2014 to 2018
$6.3MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MMayo Cancer Genetic Epidemiology Training ProgramR25CA092049 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M., VACHON, CELINE M · 2001 to 2018
$5.3MA genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8MIdentifying and validating novel susceptibility genes for breast cancerR01CA176785 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH, NATHANSON, KATHERINE L. · 2014 to 2018
$3.4MBRCA2 missense mutations and breast cancerR01CA116167 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2007 to 2011
$3.0MBRCA1 and BRCA2 missense mutations and breast cancer riskU01CA116167 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2013 to 2017
$2.7MCancer Research UK 10124Cancer Research UK 16561Medical Research Council MC_PC_14105NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA116167NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS R25 CA092049NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA182910Wellcome Trust 203477/Z/16/ZWorld Health Organization 001
Abstract
Breast cancer risks conferred by many germline missense variants in the
Indexed as
AgedAmino Acid SubstitutionAnimalsBRCA2 ProteinBreast NeoplasmsCase-Control StudiesFemaleGenotypeGerm-Line MutationHumansMiceMutation, MissenseRiskBRCA2 ProteinBRCA2 protein, human
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