Trial reportStroke2017
Baseline Hemodynamic Impairment and Future Stroke Risk in Adult Idiopathic Moyamoya Phenomenon: Results of a Prospective Natural History Study.
Registry-linked trialAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00629915 (The Role of Cerebral Hemodynamics in Moyamoya Disease), which is not on this map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cerebral Hemodynamics in Moyamoya Disease
Who cites it
12 citing papers in PubMed.
- Advances in cerebrovascular reserve function assessment for moyamoya disease.BMJ neurology open · 2026Review
- European Stroke Organisation (ESO) Guidelines on Moyamoya angiopathy Endorsed by Vascular European Reference Network (VASCERN).European stroke journal · 2023Article
- Spatial coefficient of variation of arterial spin labeling MRI for detecting hemodynamic disturbances measured withNeuroradiology · 2022Article
- A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis.Journal of magnetic resonance imaging : JMRI · 2021Article
- Multimodal evaluation of the cerebrovascular reserve in Neurofibromatosis type 1 patients with Moyamoya syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Observational
- Vessel Wall and Lumen Features in North American Moyamoya Patients.Clinical neuroradiology · 2020Article
- A critical appraisal of bypass surgery in moyamoya disease.Therapeutic advances in neurological disorders · 2020Review
- Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation.Stroke and vascular neurology · 2020Article
- Article
- Spontaneous recession of a posterior cerebral artery aneurysm concurrent with carotid rete mirabile and moyamoya-pattern collateral vessels: a case report.BMC neurology · 2019Article
- Hemodynamic Impairment Measured by Positron-Emission Tomography Is Regionally Associated with Decreased Cortical Thickness in Moyamoya Phenomenon.AJNR. American journal of neuroradiology · 2018Article
- Hemodynamics and oxygen extraction in chronic large artery steno-occlusive disease: Clinical applications for predicting stroke risk.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Colin P DerdeynFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.). colin-derdeyn@uiowa.edu.
Gregory J ZipfelFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Allyson R ZazuliaFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Patricia H DavisFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Shyam PrabhakaranFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Cristina S IvanFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Venkatesh AiyagariFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
James R SagarFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Nancy HantlerFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Lina ShinawiFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
John J LeeFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Hussain JafriFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Robert L GrubbFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
J Philip MillerFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Ralph G DaceyFrom the Department of Radiology (C.P.D.), Department of Neurology (C.P.D., P.H.D.), and Department of Neurosurgery (C.P.D.), University of Iowa Hospitals and Clinics, Iowa City; Department of Neurological Surgery (G.J.Z., R.L.G., R.G.D.), Department of Neurology (A.R.Z.), Department of Radiology (J.R.S., N.H., L.S., J.J.L., H.J.), and Division of Biostatistics (J.P.M.), Washington University School of Medicine, St Louis, MO; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.P.); Department of Neurology, University of Indiana Medical School, Indianapolis (C.S.I.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas (V.A.).
Funding
The Role of Cerebral Hemodynamics in Moya Moya DiseaseR01NS051631 · NINDS · WASHINGTON UNIVERSITY · PI DERDEYN, COLIN PIETER · 2006 to 2010
$1.6MNINDS NIH HHS R01 NS051631
Abstract
background and purposeThe purpose was to test the hypothesis that increased oxygen extraction fraction (OEF), a marker of severe hemodynamic impairment measured by positron emission tomography, is an independent risk factor for subsequent ischemic stroke in this population.
methodsAdults with idiopathic moyamoya phenomena were recruited between 2005 and 2012 for a prospective, multicenter, blindly adjudicated, longitudinal cohort study. Measurements of OEF were obtained on enrollment. Subjects were followed up for the occurrence of ipsilateral ischemic stroke at 6-month intervals. Patients were censored at the time of surgical revascularization or at last follow-up. The primary analysis was time to ischemic stroke in the territory of the occlusive vasculopathy.
resultsForty-nine subjects were followed up during a median of 3.7 years. One of 16 patients with increased OEF on enrollment had an ischemic stroke and another had an intraparenchymal hemorrhage. Three of 33 patients with normal OEF had an ischemic stroke. On a per-hemisphere basis, 21 of 79 hemispheres with moyamoya vasculopathy had increased OEF at baseline. No ischemic strokes and one hemorrhage occurred in a hemisphere with increased OEF (n=21). Sixteen patients (20 hemispheres), including 5 with increased OEF at enrollment, were censored at a mean of 5.3 months after enrollment for revascularization surgery.
conclusionsThe risk of new or recurrent stroke was lower than expected. The low event rate, low prevalence of increased OEF, and potential selection bias introduced by revascularization surgery limit strong conclusions about the association of increased OEF and future stroke risk. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00629915.
Indexed as
Neurovascular CouplingAdultAgedBrain IschemiaFemaleFollow-Up StudiesHumansMaleMiddle AgedMidwestern United StatesMoyamoya DiseaseOxygenPositron-Emission TomographyRecurrenceRisk FactorsSingle-Blind MethodOxygenarterial occlusive diseaseatherosclerosisnatural history
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NCT00629915ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.