ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- A double-blind trial of decoded neurofeedback intervention for specific phobias.Psychiatry and clinical neurosciences · 2024Trial
- Distinct Visual Pathways of Threat Retrieval in Fear-Conditioned Faces.Psychophysiology · 2026Article
- An auditory "low road" for threat processing in humans sensitive to fast temporal cues.iScience · 2026Article
- Weakening of Subcortical and Strengthening of Cortical Visual Pathways Across Early Adolescence.Human brain mapping · 2026Article
- Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings.Brain : a journal of neurology · 2026Article
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Bioinspired adaptive response speed for high-quality human-robot interactions.Science advances · 2025Article
- Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.eNeuro · 2025Article
- Investigating the hemiretinal asymmetry in emotion processing as a function of spatial frequency.Proceedings. Biological sciences · 2024Article
- Genetic and neuronal basis for facial emotion perception in humans and macaques.National science review · 2024Article
- Saccadic "inhibition" unveils the late influence of image content on oculomotor programming.Experimental brain research · 2024Article
- A double-blind trial of decoded neurofeedback intervention for specific phobias.medRxiv : the preprint server for health sciences · 2024Article
- Beyond faces: the contribution of the amygdala to visual processing in the macaque brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Looming Angry Faces: Preliminary Evidence of Differential Electrophysiological Dynamics for Filtered Stimuli via Low and High Spatial Frequencies.Brain sciences · 2024Article
- Topological cluster statistic (TCS): Toward structural connectivity-guided fMRI cluster enhancement.Network neuroscience (Cambridge, Mass.) · 2024Article
- Analysis of convolutional neural networks reveals the computational properties essential for subcortical processing of facial expression.Scientific reports · 2023Article
- Negative interpretation bias connects to real-world daily affect: A multistudy approach.Journal of experimental psychology. General · 2023Article
- Potentiated early neural responses to fearful faces are not driven by specific face parts.Scientific reports · 2023Article
- Observing cognitive processes in time through functional MRI model comparison.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is significant controversy over the existence and function of a direct subcortical visual pathway to the amygdala. It is thought that this pathway rapidly transmits low spatial frequency information to the amygdala independently of the cortex, and yet the directionality of this function has never been determined. We used magnetoencephalography to measure neural activity while human participants discriminated the gender of neutral and fearful faces filtered for low or high spatial frequencies. We applied dynamic causal modeling to demonstrate that the most likely underlying neural network consisted of a pulvinar-amygdala connection that was uninfluenced by spatial frequency or emotion, and a cortical-amygdala connection that conveyed high spatial frequencies. Crucially, data-driven neural simulations revealed a clear temporal advantage of the subcortical connection over the cortical connection in influencing amygdala activity. Thus, our findings support the existence of a rapid subcortical pathway that is nonselective in terms of the spatial frequency or emotional content of faces. We propose that that the "coarseness" of the subcortical route may be better reframed as "generalized."
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.