Evidence map›Paper›PMID 28283555›Full record

ReviewMolecular pharmacology2017

Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia.

Mei-Fei Yueh, Shujuan Chen, Nghia Nguyen, Robert H Tukey

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  15. HumanizedDrug metabolism and disposition: the biological fate of chemicals · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mei-Fei YuehLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California mfyueh@ucsd.edu.
Shujuan ChenLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California.
Nghia NguyenLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California.
Robert H TukeyLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California.
University of California, San Diego · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Xenobiotic sensors PXR and CAR and regulation of the UGT1 locusR01GM086713 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2009 to 2017
$2.6M
Neonatal hyperbilirubinemia in a humanized UGT1 animal modelR01GM100481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2012 to 2015
$1.3M
The antimicrobial triclosan is a potent liver tumor promoterR21ES023906 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUEH, MEI-FEI · 2015 to 2016
$426k
NCoR1 and developmental expression of intestinal xenobiotic processing genesR21ES024818 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHUJUAN · 2015 to 2016
$426k
NIEHS NIH HHS P42 ES010337NIEHS NIH HHS R21 ES023906NIEHS NIH HHS R21 ES024818NIGMS NIH HHS R01 GM086713NIGMS NIH HHS R01 GM100481
6 · The paper itself

Abstract

Hyperbilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common clinical diagnoses in both premature and term newborns. Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental stage, acts as a bottleneck to bilirubin elimination and predisposes the infant to high total serum bilirubin levels. Although neonatal jaundice is mostly benign, excessively high levels of serum bilirubin in a small percentage of newborns can cause bilirubin-induced neurologic dysfunction, potentially leading to permanent brain damage, a condition known as

Indexed as

AnimalsBilirubinDietGlucuronosyltransferaseHumansHyperbilirubinemia, NeonatalInfant, NewbornUGT1A1 EnzymeBilirubinGlucuronosyltransferaseUGT1A1 Enzyme

Identifiers

PMID28283555
PMCPMC5416747
OpenAlexW2591750909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.