ArticleInternational journal of molecular sciences2017
Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Theoretical Analysis of Electronic, Vibrational Properties, and Noncovalent Interactions in Methylxanthines: Monomers to Antiparallel Dimers.ACS omega · 2026Article
- Caffeine Biotransformation in Zebrafish Larvae: Integrated LC-MS/MS Quantification and FTIR Spatial Mapping.Molecules (Basel, Switzerland) · 2026Article
- Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy.Communications biology · 2026Article
- Caffeine removal in wastewater: a comprehensive review of current treatment plants and small-scale innovations.Environmental technology reviews · 2025Article
- Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos.Frontiers in psychiatry · 2025Article
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- MiR92b-3p synthetic analogue impairs zebrafish embryonic development, leading to ocular defects, decreased movement and hatching rate, and increased mortality.Journal of applied genetics · 2023Article
- Bi-Allelic Mutations in ZebrafishInternational journal of molecular sciences · 2022Article
- The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds.Disease models & mechanisms · 2022Article
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- Caffeine Inhibits Direct and Indirect Angiogenesis in Zebrafish Embryos.International journal of molecular sciences · 2021Article
- An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy.Brain : a journal of neurology · 2021Article
- Article
- The Downregulation ofFrontiers in cell and developmental biology · 2020Article
- Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos.Neuromolecular medicine · 2019Article
- Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model.Nanomaterials (Basel, Switzerland) · 2019Article
- Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test.International journal of molecular sciences · 2019Article
- Zebrafish as a Model to Evaluate Nanoparticle Toxicity.Nanomaterials (Basel, Switzerland) · 2018Review
- Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos.BMC pharmacology & toxicology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish embryo is emerging as an important tool for behavior analysis as well as toxicity testing. In this study, we compared the effect of nine different methylxanthine drugs using zebrafish embryo as a model. We performed behavioral analysis, biochemical assay and Fish Embryo Toxicity (FET) test in zebrafish embryos after treatment with methylxanthines. Each drug appeared to behave in different ways and showed a distinct pattern of results. Embryos treated with seven out of nine methylxanthines exhibited epileptic-like pattern of movements, the severity of which varied with drugs and doses used. Cyclic AMP measurement showed that, despite of a significant increase in cAMP with some compounds, it was unrelated to the observed movement behavior changes. FET test showed a different pattern of toxicity with different methylxanthines. Each drug could be distinguished from the other based on its effect on mortality, morphological defects and teratogenic effects. In addition, there was a strong positive correlation between the toxic doses (TC
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