ArticleMolecules (Basel, Switzerland)2017
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
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Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling.ChemMedChem · 2026Article
- 3-(Pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives: synthesis,RSC medicinal chemistry · 2026Article
- Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach.Journal of medicinal chemistry · 2025Article
- Synthesis and Antimicrobial Evaluation of Chroman-4-One and Homoisoflavonoid Derivatives.Molecules (Basel, Switzerland) · 2025Article
- Drug Repurposing for Kala-Azar.Pharmaceutics · 2025Article
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- Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-ACS infectious diseases · 2024Article
- Synthesis, biological assessment, and computational investigations of nifedipine and monastrol analogues as anti-leishmanial major and anti-microbial agents.Molecular diversity · 2023Article
- Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.Journal of medicinal chemistry · 2022Article
- Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADPActa crystallographica. Section F, Structural biology communications · 2022Article
- Article
- Chromanone-A Prerogative Therapeutic Scaffold: An Overview.Arabian journal for science and engineering · 2022Review
- Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Synthesis and Evaluation of Novel 2,2-Dimethylthiochromanones as Anti-Leishmanial Agents.Molecules (Basel, Switzerland) · 2021Article
- QSAR Modeling for Multi-Target Drug Discovery: Designing Simultaneous Inhibitors of Proteins in Diverse Pathogenic Parasites.Frontiers in chemistry · 2021Article
- An Overview on the Therapeutics of Neglected Infectious Diseases-Leishmaniasis and Chagas Diseases.Frontiers in chemistry · 2021Review
- A Chemographic Audit of anti-Coronavirus Structure-activity Information from Public Databases (ChEMBL).Molecular informatics · 2020Article
- Virtual Screening and the In Vitro Assessment of the Antileishmanial Activity of Lignans.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 4 countries.
Flavio Di PisaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy. dipisa2@unisi.it.
Giacomo LandiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy. landi31@unisi.it.
Lucia Dello IaconoDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy. delloiacono3@unisi.it.
Cecilia PozziDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy. pozzi4@unisi.it.
Chiara BorsariDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy. chiara.borsari@unimore.it.
Stefania FerrariDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy. stefania.ferrari@unimore.it.
Matteo SantucciDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy. matteo.santucci@unimore.it.
Nuno SantaremInstitute for Molecular and Cell Biology, 4150-180 Porto, Portugal and Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal. santarem@ibmc.up.pt.
Anabela Cordeiro-da-SilvaInstitute for Molecular and Cell Biology, 4150-180 Porto, Portugal and Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal. cordeiro@ibmc.up.pt.
Carolina B MoraesLaboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas SP13083-100, Brazil. carolinaborsoi@gmail.com.
Laura M AlcantaraLaboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas SP13083-100, Brazil. laura.alcantara@lnbio.cnpem.br.
Vanessa FontanaLaboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas SP13083-100, Brazil. fontana_vanessa@yahoo.com.br.
Lucio H Freitas-JuniorLaboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas SP13083-100, Brazil. lucio.freitas@butantan.gov.br.
Sheraz GulFraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany. Sheraz.Gul@ime.fraunhofer.de.
Maria KuzikovFraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany. Maria.Kuzikov@ime.fraunhofer.de.
Birte BehrensFraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany. Birte.Behrens@ime.fraunhofer.de.
Ina PöhnerMolecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, 69118 Heidelberg, Germany. ina.poehner@h-its.org.
Rebecca C WadeMolecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, 69118 Heidelberg, Germany. rebecca.wade@h-its.org.
Maria Paola CostiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy. mariapaola.costi@unimore.it.
Stefano ManganiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy. stefano.mangani@unisi.it.
University of Siena · ITUniversity of Modena and Reggio Emilia · ITFraunhofer Institute for Molecular Biology and Applied Ecology · DELaboratório Nacional de Ciência e Tecnologia do Bioetanol · BRi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTHeidelberg Institute for Theoretical Studies · DEHeidelberg University · DEInstituto Butantan · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold. Three chroman-4-one analogues (
Indexed as
Antiparasitic AgentsBinding SitesChromansEnzyme ActivationInhibitory Concentration 50Leishmania majorMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureOxidoreductasesProtein BindingTrypanosoma brucei bruceiAntiparasitic AgentsChromansOxidoreductasespteridine reductasechroman-4-onechromen-4-onecrystallographic studiesLeishmania spp.pteridine reductase 1Trypanosoma brucei
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