ArticleInternational journal of molecular sciences2017
Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW 264.7 Macrophages and Dendritic Cells.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Elderberry (Sambucus nigra L.): an ethnopharmacological, phytochemical and biological review for a prospective nutraceutical plant.Inflammopharmacology · 2026Review
- In vivo biocompatibility of elderberry-enriched carboxymethyl chitosan in soft tissue and calvaria bone defects.BMC oral health · 2025Article
- Main Dietary Patterns for Healthy Aging and Well-Being.Nutrients · 2025Review
- Anti-Inflammatory Mechanisms ofJournal of microbiology and biotechnology · 2025Article
- Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition.Molecules (Basel, Switzerland) · 2024Article
- GenusInternational journal of molecular sciences · 2024Review
- Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus.Journal of inflammation (London, England) · 2024Review
- In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Evaluation of the anti-obesity effect ofFrontiers in pharmacology · 2024Article
- Health-Promoting Properties: Anti-Inflammatory and Anticancer Properties ofMolecules (Basel, Switzerland) · 2023Review
- Elderberry extract improves molecular markers of endothelial dysfunction linked to atherosclerosis.Food science & nutrition · 2023Article
- Elderberry (Food chemistry: X · 2022Article
- Short- and Long-Term Effects of a Prebiotic Intervention with Polyphenols Extracted from European Black Elderberry-Sustained Expansion ofJournal of personalized medicine · 2022Article
- The Effects of Blueberry Phytochemicals on Cell Models of Inflammation and Oxidative Stress.Advances in nutrition (Bethesda, Md.) · 2022Review
- Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.International journal of molecular sciences · 2022Article
- Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction.Pharmaceuticals (Basel, Switzerland) · 2022Review
- A Flavonoid-Rich Extract ofMaterials (Basel, Switzerland) · 2022Article
- Article
- Structural characterization, anti-inflammatory and glycosidase inhibitory activities of two new polysaccharides from the root ofRSC advances · 2021Article
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of complement activity and inhibition of nitric oxide (NO) production by macrophages and dendritic cells may have therapeutic value in inflammatory diseases. Elderberry and elderflower extracts, constituents, and metabolites were investigated for their effects on the complement system, and on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages and murine dendritic D2SC/I cells. The EtOH crude extracts from elderberry and elderflower and the isolated anthocyanins and procyanidins possessed strong complement fixating activity and strong inhibitory activity on NO production in RAW cells and dendritic cells. Phenolic compounds in the range of 0.1-100 µM showed a dose-dependent inhibition of NO production, with quercetin, rutin, and kaempferol as the most potent ones. Among the metabolites, caffeic acid and 3,4-dihydroxyphenylacetic acid showed the strongest inhibitory effects on NO production in both cell lines, without having cytotoxic effect. Only 4-methylcatechol was cytotoxic at the highest tested concentration (100 µM). Elderberry and elderflower constituents may possess inflammatory modulating activity, which increases their nutritional value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.