Evidence map›Paper›PMID 28282852›Full record

ReviewHealthcare (Basel, Switzerland)2017

Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable Diseases.

Janis Baird, Chandni Jacob, Mary Barker, Caroline H D Fall, Mark Hanson, Nicholas C Harvey, Hazel M Inskip, Kalyanaraman Kumaran, Cyrus Cooper

Open access · goldAbstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 5 pooled it
28.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 5 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Janis BairdMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. jb@mrc.soton.ac.uk.
Chandni JacobInstitute of Developmental Sciences, University of Southampton, Southampton S016 5YA, UK. chandni.jacob@gmail.com.
Mary BarkerMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. meb@mrc.soton.ac.uk.
Caroline H D FallMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. chdf@mrc.soton.ac.uk.
Mark HansonInstitute of Developmental Sciences, University of Southampton, Southampton S016 5YA, UK. M.Hanson@soton.ac.uk.
Nicholas C HarveyMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. nch@mrc.soton.ac.uk.
Hazel M InskipMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. hmi@mrc.soton.ac.uk.
Kalyanaraman KumaranMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. kk@mrc.soton.ac.uk.
Cyrus CooperMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK. cc@mrc.soton.ac.uk.
MRC Lifecourse Epidemiology Unit · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Southampton · GB

Funding

Arthritis Research UK 17702Arthritis Research UK 21231British Heart Foundation RG/15/17/31749Department of Health 10/33/04Department of Health HTA/10/33/04Medical Research Council G0400491Medical Research Council G106/1077Medical Research Council MC_U147574224Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4Medical Research Council MR/N011848/1Versus Arthritis 17702Versus Arthritis 21231
6 · The paper itself

Abstract

Non-communicable diseases (NCDs), such as cardiovascular disease and osteoporosis, affect individuals in all countries worldwide. Given the very high worldwide prevalence of NCDs across a range of human pathology, it is clear that traditional approaches targeting those at most risk in older adulthood will not efficiently ameliorate this growing burden. It will thus be essential to robustly identify determinants of NCDs across the entire lifecourse and, subsequently, appropriate interventions at every stage to reduce an individual's risk of developing these conditions. A lifecourse approach has the potential to prevent NCDs, from before conception through fetal life, infancy, childhood, adolescence, adulthood and into older age. In this paper, we describe the origins of the lifecourse concept, the importance of early life influences, for example during pregnancy, examine potential underlying mechanisms in both cell biology and behavior change, and finally describe current efforts to develop interventions that take a lifecourse approach to NCD prevention. Two principal approaches to improving women's nutritional status are outlined: nutritional supplementation and behavior change.

Indexed as

interventionlifecourseNCDs (non-communicable diseases)prevention

Identifiers

PMID28282852
PMCPMC5371920
OpenAlexW2592419144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.