ArticlePloS one2017
Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 70 citations in OpenAlex.
- An overview of innate cellular immune responses against hypervirulentEmerging microbes & infections · 2026Review
- Pharmaceutical innovation in advanced nanomedicine for the treatment of hypervirulent and multidrug-resistant Klebsiella pneumoniae infections.Archives of microbiology · 2026Review
- Article
- Therapeutic efficacy of a K1-specific bacteriophage against hypervirulent Klebsiella pneumoniae in a mouse infection model.Virologica Sinica · 2026Article
- Genome-Wide Association of ST, K-, and O-Locus Diversity with Virulence in Indian Klebsiella pneumoniae via Targeted Phenotypic Validation.Current microbiology · 2026Article
- Prevalence, Virulence, and Pathogenic Mechanisms of Mastitis-AssociatedVeterinary sciences · 2026Review
- A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Therapeutic effect of eravacycline against carbapenem-resistant hypervirulentAntimicrobial agents and chemotherapy · 2026Article
- Enhanced pathogen detection and gut microbiome alterations in pyogenic liver abscess: insights from next-generation sequencing.Gut pathogens · 2026Article
- Immune evasion byAIMS microbiology · 2026Article
- Hypervirulent and Drug-ResistantInternational journal of general medicine · 2026Review
- Exploring the IS-capades ofMicrobial genomics · 2026Article
- Interventional treatment of a bacterial embolus in the retrohepatic inferior vena cava secondary to invasive Klebsiella pneumoniae liver abscess syndrome: a case report and literature review.Frontiers in cardiovascular medicine · 2026Article
- Article
- New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae.Folia microbiologica · 2025Review
- Mechanisms governing bacterial capsular polysaccharide attachment and chain length.Annals of the New York Academy of Sciences · 2025Review
- HypervirulentPharmaceuticals (Basel, Switzerland) · 2025Review
- Molecular epidemiological analysis and research on resistance and virulence of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital from 2016 to 2023.BMC microbiology · 2025Article
- Article
- Phage therapy for Klebsiella pneumoniae: Understanding bacteria-phage interactions for therapeutic innovations.PLoS pathogens · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypervirulent Klebsiella pneumoniae (HvKP) is hypermucoviscous organism, carrying genes of rmpA and aerobactin, causing serious community-acquired infection and metastatically spread in young healthy hosts. Neutrophils play an important role during innate immune response against bacterial infection by phagocytosis and neutrophil extracellular traps (NETs). Whether neutrophils can effectively defend against HvKP remains unclear. In this study, we observed that the HvKP was significantly more resistant to neutrophil-mediated phagocytosis and intracellular killing than classic Klebsiella pneumoniae (cKP) isolates. Although both HvKP and cKP induced NETs under scanning electron microscopy and confocal microscopy, more cKP than HvKP were trapped in NETs, and the killing by intracellular and extracellular mechanisms of neutrophils was detected only on cKP. Together, our results demonstrated that HvKP resisted to both intracellular and extracellular killing of neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.