ArticlePloS one2017
High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Morphometric and carcass traits of indigenous chickens under the prevailing scavenging production system in Farta District of South Gondar Zone, Amhara, Ethiopia.Veterinary and animal science · 2026Article
- Bone growth and metabolism in broilers exposed to dietary PUFA or cyclical heat stress under two levels of dietary vitamins and minerals.Frontiers in physiology · 2026Article
- Landscape genomics reveals regions associated with adaptive phenotypic and genetic variation in Ethiopian indigenous chickens.BMC genomics · 2024Article
- Influencing factors of bone mass abnormalities among postmenopausal women in Tibet, China.BMC public health · 2023Article
- Article
- Increased sizes and improved qualities of tibia bones by myostatin mutation in Japanese quail.Frontiers in physiology · 2022Article
- Hypoxia during incubation and its effects on broiler's embryonic development.Poultry science · 2021Review
- Lactobacillus rhamnosus JYLR-005 Prevents Thiram-Induced Tibial Dyschondroplasia by Enhancing Bone-Related Growth Performance in Chickens.Probiotics and antimicrobial proteins · 2021Article
- LPS-induced inflammation disorders bone modeling and remodeling by inhibiting angiogenesis and disordering osteogenesis in chickens.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens.BMC genomics · 2020Article
- Tibial growth plate vascularization is inhibited by the dithiocarbamate pesticide thiram in chickens: potential relationship to peripheral platelet counts alteration.Environmental science and pollution research international · 2019Article
- Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens.Scientific reports · 2018Article
- Tibial dyschondroplasia is closely related to suppression of expression of hypoxia-inducible factors 1α, 2α, and 3α in chickens.Journal of veterinary science · 2018Article
- Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens.Scientific reports · 2017Article
- Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes.International journal of biological sciences · 2017Article
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Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tibial dyschondroplasia (TD) is one of the most common problems in the poultry industry and leads to lameness by affecting the proximal growth plate of the tibia. However, due to the unique environmental and geographical conditions of Tibet, no case of TD has been reported in Tibetan chickens (TBCs). The present study was designed to investigate the effect of high altitude hypoxia on blood parameters and tibial growth plate development in chickens using the complete blood count, morphology, and histological examination. The results of this study showed an undesirable impact on the overall performance, body weight, and mortality of Arbor Acres chickens (AACs) exposed to a high altitude hypoxic environment. However, AACs raised under hypoxic conditions showed an elevated number of red blood cells (RBCs) and an increase in hemoglobin and hematocrit values on day 14 compared to the hypobaric normoxia group. Notably, the morphology and histology analyses showed that the size of tibial growth plates in AACs was enlarged and that the blood vessel density was also higher after exposure to the hypoxic environment for 14 days, while no such change was observed in TBCs. Altogether, our results revealed that the hypoxic environment has a potentially new role in increasing the blood vessel density of proximal tibial growth plates to strengthen and enhance the size of the growth plates, which may provide new insights for the therapeutic manipulation of hypoxia in poultry TD.
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