Evidence map›Paper›PMID 28282287›Full record

ArticleeLife2017

Driving cancer evolution.

Devon M Fitzgerald, Susan M Rosenberg

Abstract readComment
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Devon M FitzgeraldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-2480-7269
Susan M RosenbergDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-1444-473X

Funding

MOLECULAR MECHANISMS OF STRESS-INDUCED MUTATIONR35GM122598 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2017 to 2020
$2.4M
NIGMS NIH HHS R35 GM122598
6 · The paper itself

Abstract

Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.

Indexed as

NeoplasmsTransforming Growth Factor betaCD24 AntigenDNADNA RepairGenetic VariationHumansHyaluronan ReceptorsCD24 AntigenCD24 protein, humanCD44 protein, humanDNAHyaluronan ReceptorsTransforming Growth Factor betacancer biologycell biologycopy number alterationdrug adaptabilitygenetic diversityhumanintra-tumor heterogeneitytumor evolutiontumor fitness

Identifiers

PMID28282287
PMCPMC5345930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.