Evidence map›Paper›PMID 28282278›Full record

ReviewJournal of oncology practice2017

Functio Laesa: Cancer Inflammation and Therapeutic Resistance.

Mingen Liu, Anusha Kalbasi, Gregory L Beatty

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oncology practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. What Exactly Is Inflammation (and What Is It Not?).International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Mingen LiuUniversity of Pennsylvania, Philadelphia, PA; and University of California, Los Angeles, CA.
Anusha KalbasiUniversity of Pennsylvania, Philadelphia, PA; and University of California, Los Angeles, CA.
Gregory L BeattyUniversity of Pennsylvania, Philadelphia, PA; and University of California, Los Angeles, CA.

Funding

Targeting the liver for immunotherapy in pancreatic cancerR01CA197916 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Gregory L Beatty · 2016 to 2026
$3.7M
Pro- and anti-phagocytic signals on pancreatic cancer regulate tumor macrophagesF30CA196124 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LIU, MINGEN · 2015 to 2017
$126k
NCI NIH HHS F30 CA196124NCI NIH HHS R01 CA197916
6 · The paper itself

Abstract

Tumor, calor, rubor, and dolor describe four cardinal signs of inflammation. The fifth-functio laesa, or loss of function-was promulgated by Rudolf Virchow, who, in the 19th century, also noted an intricate link between inflammation and cancer. However, the role of cancer inflammation in driving loss of therapeutic efficacy has only recently been fully appreciated, as a result of molecular and immunohistochemical approaches applied in clinical medicine and the availability of novel agents for modulating inflammation. This review focuses on clinical evidence from solid malignancies that have shaped our view of how the immune system regulates cancer development, progression, and response to treatment. Understanding the multifaceted relationship between inflammation and patient outcomes has the potential to advance prognostic tools and uncover therapeutic opportunities for improving clinical outcomes.

Indexed as

HumansInflammationNeoplasms

Identifiers

PMID28282278
PMCPMC5456257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.