Evidence map›Paper›PMID 28282140›Full record

ArticleThe Journal of organic chemistry2017

Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol.

Xiao-Kang Zhang, Feng Liu, William D Fiers, Wen-Mei Sun, Jun Guo, Zheng Liu, Courtney C Aldrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. New Chromane-Based Derivatives as Inhibitors ofMolecules (Basel, Switzerland) · 2018
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiao-Kang ZhangKey Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, People's Republic of China.
Feng LiuDepartment of Medicinal Chemistry, University of Minnesota , 308 Harvard Street Southeast, 8-174 WDH, Minneapolis, Minnesota 55455, United States.
William D FiersDepartment of Medicinal Chemistry, University of Minnesota , 308 Harvard Street Southeast, 8-174 WDH, Minneapolis, Minnesota 55455, United States.
Wen-Mei SunKey Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, People's Republic of China.
Jun GuoKey Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, People's Republic of China.ORCID 0000-0002-2097-5054
Zheng LiuKey Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, People's Republic of China.ORCID 0000-0002-3696-339X
Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota , 308 Harvard Street Southeast, 8-174 WDH, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-9261-594X
Central China Normal University · CNUniversity of Minnesota · US

Funding

Design of Antituberculosis Agents that Target Siderophore BiosynthesisR01AI070219 · NIAID · UNIVERSITY OF MINNESOTA · PI ALDRICH, COURTNEY C · 2006 to 2013
$2.2M
NIAID NIH HHS R01 AI070219
6 · The paper itself

Abstract

In order to survive in a mammalian host, Mycobacterium tuberculosis (Mtb) produces aryl-capped siderophores known as the mycobactins for iron acquisition. Salicylic acid is a key building block of the mycobactin core and is synthesized by the bifunctional enzyme MbtI, which converts chorismate into isochorismate via a S

Indexed as

BromobenzenesCyclohexenesDose-Response Relationship, DrugEnzyme InhibitorsLyasesMolecular StructureMycobacterium tuberculosisStructure-Activity Relationship3-bromo-3,5-cyclohexadiene-1,2-diolBromobenzenesCyclohexenesEnzyme InhibitorsLyasessalicylate synthetase

Identifiers

PMID28282140
PMCPMC5588064
OpenAlexW2591945908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.