ArticleeLife2017
Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Quorum sensing underlies the establishment and maintenance of marginal zone B cells.bioRxiv : the preprint server for biology · 2026Article
- Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis.Frontiers in immunology · 2026Article
- Mild HIV-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells.Cell systems · 2025Article
- Article
- Partially-functional exhausted CD8+ T cells can contribute to short-term viral suppression: a computational prediction for children with perinatal HIV.bioRxiv : the preprint server for biology · 2025Article
- Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.Immunity · 2025Article
- A variational deep-learning approach to modeling memory T cell dynamics.PLoS computational biology · 2025Article
- Tissue-resident memory CD4eLife · 2025Article
- A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.Science immunology · 2025Article
- How are estimated cellular turnover rates influenced by the dynamics of a source population?PLoS computational biology · 2025Article
- Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparingmSystems · 2025Article
- A variational deep-learning approach to modeling memory T cell dynamics.bioRxiv : the preprint server for biology · 2025Article
- Engineering memory T cells as a platform for long-term enzyme replacement therapy in lysosomal storage disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- IL-7Rα on CD4Journal of neuroinflammation · 2024Article
- The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.PLoS biology · 2024Article
- The dynamics and longevity of circulating CD4bioRxiv : the preprint server for biology · 2024Article
- Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity.JCI insight · 2024Article
- Differentiation marker-negative CD4bioRxiv : the preprint server for biology · 2024Article
- Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence.Nature communications · 2023Article
- KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.The Journal of clinical investigation · 2023Article
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5 authors.
Funding
Abstract
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to the maintenance of memory compartments. Here, we characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates of influx of new cells and using detailed timecourses of DNA labelling that also distinguish the behaviour of recently divided and quiescent cells. We find that both effector and central memory CD4 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflows of new cells sourced from the naive pool strongly impact estimates of memory cell lifetimes and division rates. We also demonstrate that the maintenance of CD4 T cell memory subsets in healthy mice is unexpectedly and strikingly reliant on this replenishment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.