Evidence map›Paper›PMID 28281242›Full record

ArticleJournal of cardiovascular translational research2017

Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.

Vaithinathan Selvaraju, Sumanth C Suresh, Mahesh Thirunavukkarasu, Jayakanthan Mannu, Jocelyn L C Foye, Premendu P Mathur, J Alexander Palesty, Juan A Sanchez, David W McFadden, Nilanjana Maulik

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection.Journal of cardiovascular development and disease · 2018
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vaithinathan SelvarajuMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA.
Sumanth C SureshMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA.
Mahesh ThirunavukkarasuMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA.
Jayakanthan MannuCentre for Bioinformatics, Pondicherry University, Pondicherry, India.
Jocelyn L C FoyeESSEN BioScience, Ann Arbor, MI, USA.
Premendu P MathurCentre for Bioinformatics, Pondicherry University, Pondicherry, India.
J Alexander PalestyDepartment of Surgery, Saint Mary's Hospital, Waterbury, CT, USA.
Juan A SanchezMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA.
David W McFaddenDepartment of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA.
Nilanjana MaulikMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, Farmington Avenue, Farmington, CT, USA. nmaulik@uchc.edu.
University of Connecticut · USPondicherry University · INEssen BioScience (United States) · USSt Mary's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the effects of overexpressing HSPA12B on angiogenesis and myocardial function by intramyocardial administration of adenovirus encoding HSPA12B (Ad. HSPA12B) in a streptozotocin-induced diabetic rat subjected to myocardial infarction. Rats were divided randomly into six groups: control sham (CS) + Ad.LacZ, control myocardial infarction (CMI) + Ad.LacZ, control MI + Ad.HSPA12B, diabetic sham (DS) + Ad.LacZ, diabetic MI + Ad.LacZ and diabetic MI + Ad.HSPA12B. Following MI or sham surgery, the respective groups received either Ad.LacZ or Ad.HSPA12B via intramyocardial injections. We observed increased capillary and arteriolar density along with reduced fibrosis and preserved heart functions in DMI-AdHSPA12B compared to DMI-AdLacZ group. Western blot analysis demonstrated enhanced HSPA12B, vascular endothelial growth factor (VEGF), thioredoxin-1 (Trx-1) expression along with decreased expression of thioredoxin interacting protein (TXNIP) and A kinase anchoring protein 12 (AKAP12) in the DMI-AdHSPA12B compared to DMI-AdLacZ group. Our findings reveal that HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute MI.

Indexed as

Ventricular Function, LeftA Kinase Anchor ProteinsAnimalsCarrier ProteinsCell Cycle ProteinsCell MovementCells, CulturedDiabetes Mellitus, ExperimentalFibrosisGene Expression RegulationGenetic TherapyHSP70 Heat-Shock ProteinsHumansHuman Umbilical Vein Endothelial CellsMolecular Docking SimulationMyocardial InfarctionAKAP12 protein, humanAkap12 protein, ratA Kinase Anchor ProteinsCarrier ProteinsCell Cycle ProteinsHSP70 Heat-Shock ProteinsHSPA12B protein, humanHSPA12B protein, ratTXNIP protein, ratVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratAKAP12All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.Cardiovascular diseaseCommunicated by: Associate Editor Lorrie Kirshenbaum oversaw the review of this article.Gene therapyMyocardial infarctionVaithinathan Selvaraju and Sumanth C Suresh both contributed equallyVEGF

Identifiers

PMID28281242
OpenAlexW2592960001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.