ArticleJournal of muscle research and cell motility2017
Mouse soleus (slow) muscle shows greater intramyocellular lipid droplet accumulation than EDL (fast) muscle: fiber type-specific analysis.
Article in Journal of muscle research and cell motility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Thermal stimulation promotes myogenic differentiation through enhanced glucose uptake and transient lipid droplet accumulation in C2C12 cells.In vitro cellular & developmental biology. Animal · 2026Article
- Effects of bed rest and immobilization on intramuscular and intermuscular adipose tissue: A systematic review.Experimental physiology · 2026Review
- Metabolic stress and muscle mechanics: Acute response of isolated soleus and EDL muscles to prolonged fasting in mice with distinct muscle phenotypes.Biology open · 2025Article
- Muscle memory of exercise optimizes mitochondrial metabolism to support skeletal muscle growth.American journal of physiology. Cell physiology · 2025Article
- Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages.Science China. Life sciences · 2025Article
- Myosin relaxation states in skeletal muscle fibers of rats and mice: Effects of sex and adiposity.Physiological reports · 2025Article
- Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats.Nutrients · 2025Article
- Non-muscle myosin IIC predominantly expressed in the slow-twitch skeletal muscles impedes age-related muscle weakness.PloS one · 2025Article
- Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.American journal of translational research · 2025Article
- Article
- Identification of porcine fast/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes.Journal of animal science and biotechnology · 2024Article
- Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.Scientific reports · 2024Article
- Alterations in skeletal muscle morphology and mechanics in juvenile male Sprague Dawley rats exposed to a high-fat high-sucrose diet.Scientific reports · 2023Article
- Up- and Downregulated Genes after Long-Term Muscle Atrophy Induced by Denervation in Mice Detected Using RNA-Seq.Life (Basel, Switzerland) · 2023Article
- Local and systemic administration of AAV vectors with alphaherpesvirus latency-associated promoter 2 drives potent transgene expression in mouse liver, kidney, and skeletal muscle.Journal of virological methods · 2023Article
- Space Omics and Tissue Response in Astronaut Skeletal Muscle after Short and Long Duration Missions.International journal of molecular sciences · 2023Article
- Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics.Skeletal muscle · 2022Article
- Glycogen Kinetics of Wistar Rats: Different Exercise Intensities and Tissue Analyzed Influence.International journal of exercise science · 2022Article
- Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice.Bosnian journal of basic medical sciences · 2021Article
- Discovering fiber type architecture over the entire muscle using data-driven analysis.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle is the main tissue of lipid metabolism and accordingly is critical for homeostasis and energy production; however, the determinants of lipid accumulation in skeletal muscle are unknown. Here, we examined whether the soleus muscle (predominantly slow-twitch fibers) has a higher lipid accumulation capacity than that of the extensor digitorum longus (EDL, predominantly fast-twitch fibers) muscle in mice. Soleus and EDL muscles were harvested from male C57BL/6J mice. The mRNA levels of genes involved in fatty acid import and triglyceride synthesis and accumulation were examined in soleus and EDL muscles. The intramyocellular lipid (IMCL) droplets of muscle cross sections and isolated single fibers were visualized by staining with BODIPY493/503, and fiber types were determined by immunofluorescent detection of myosin heavy chain (MyHC) isoforms. We detected higher mRNA expression of genes related to lipid accumulation in the soleus than the EDL. We also observed a marked increase of IMCL in single fibers from the soleus, but not the EDL, after treatment with a high-fat diet plus denervation. Interestingly, greater accumulation of IMCL droplets was observed in type 2A and 2X fibers (MyHC2A- and MyHC2X-positive fibers) than type 1 fibers (MyHC1-positive fibers) in soleus muscles. These results suggest that the soleus contains more IMCL owing to the higher population of type 2A fibers, and the difference in lipid accumulation between the soleus and EDL could depend on fiber type composition.
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