Evidence map›Paper›PMID 28280965›Full record

ArticleMolecular imaging and biology2017

Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [

Bin Shen, Jun Hyung Park, Trine Hjørnevik, Peter W Cipriano, Daehyun Yoon, Praveen K Gulaka, Dawn Holly, Deepak Behera, Bonnie A Avery, Sanjiv S Gambhir and 3 more

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03556137 phase1unknown statusnot on this mapstarted 2018, after this paper: background citation

Use of [18F]FTC-146 PET/MRI in the Diagnosis of Chronic Pain

TypeinterventionalSponsorStanford UniversityRan2018 to 2024Enrolled190ConditionsNeuropathic Pain, Nociceptive Pain, Mixed Pain (Nociceptive and Neuropathic), Spinal PainArms[18F]FTC-146
NCT04314856 phase1withdrawnnot on this mapstarted 2021, after this paper: background citation

Sigma-1 Receptors: A Novel Clinical Target in Fragile X Syndrome

TypeinterventionalSponsorGuido A. Davidzon, MD, SMRan2021 to 2022Enrolled0ConditionsFragile X Syndrome (FXS)Arms18F-FTC-146
NCT06599151 phase1not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Use of (18F)FTC-146 PET_MRI for Characterizing Chronic Pain Phenotypes in Chronic Pain Patients with Spinal or Peripheral Nerve Origin

TypeinterventionalSponsorStanford UniversityRan2024 to 2030Enrolled200ConditionsNerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)Arms[18F]FTC-146
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Prospective comparison of [EJNMMI research · 2023
    Article
  6. Article
  7. Multi-Target Directed Ligands (MTDLs) Binding the σInternational journal of molecular sciences · 2021
    Review
  8. RSC medicinal chemistry · 2021
    Review
  9. Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2020
    Article
  10. Article
  11. Evaluation ofTheranostics · 2020
    Article
  12. Article
  13. Biodistribution and Radiation Dosimetry ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Bin ShenMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Jun Hyung ParkMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Trine HjørnevikMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Peter W CiprianoMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Daehyun YoonRadiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, CA, 94305, USA.
Praveen K GulakaMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Dawn HollyMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Deepak BeheraMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Bonnie A AveryDepartment of Pharmaceutics, P1-27, University of Florida, Gainesville, FL, 32610, USA.
Sanjiv S GambhirMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.
Christopher R McCurdyDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Sandip BiswalDepartment of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 300 Pasteur Drive S-068B, Stanford, CA, 94305, USA. biswal@stanford.edu.
Frederick T ChinMolecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA. chinf@stanford.edu.
Stanford University · USUniversity of Florida · USOslo University Hospital · NO

Funding

Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI CONTAG, CHRISTOPHER H · 2005 to 2014
$18.2M
Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
Novel Pharmacologic Interventions for Drugs of AbuseR01DA023205 · NIDA · UNIVERSITY OF MISSISSIPPI · PI MCCURDY, CHRISTOPHER R · 2007 to 2011
$1.7M
National Cancer Institute P50 CA114747National Institute of General Medical Sciences P20 GM104932National Institute on Drug Abuse R01 DA023205
6 · The paper itself

Abstract

purposeSigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously reported S1R radioligand, [ PROCEDURES: [

results[

conclusionA reliable and automated radiosynthesis for providing routine clinical-grade [

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyAdultAzepinesBenzothiazolesFemaleHumansMaleTissue Distribution6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo(d)thiazol-2(3H)-oneAzepinesBenzothiazoles[18F]FTC-146Automated radiosynthesisClinicalPET/MRIRadiopharmaceuticalssigma-1 receptor

Identifiers

PMID28280965
OpenAlexW2594215236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.