Evidence map›Paper›PMID 28280881›Full record

ArticlePsychopharmacology2017

Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms.

A Merchán, S V Navarro, A B Klein, S Aznar, L Campa, C Suñol, M Moreno, P Flores

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  4. A review of the neuropharmacological profile of schedule-induced polydipsia.Journal of the experimental analysis of behavior · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

A MerchánDepartment of Psychology, University of Almería, CeiA3, Carretera de Sacramento s/n, 04120, Almería, Spain.
S V NavarroDepartment of Psychology, University of Almería, CeiA3, Carretera de Sacramento s/n, 04120, Almería, Spain.
A B KleinDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100, Copenhagen, Denmark.
S AznarResearch Laboratory for Stereology and Neuroscience, Bispebjerg and Frederiksberg Hospitals, Copenhagen University Hospital, 2300, Copenhagen, Denmark.
L CampaInstitute of Biomedical Research of Barcelona, IIBB-CSIC-IDIBAPS, CIBERESP (CS), CIBERSAM (LC), 08028, Barcelona, Spain.
C SuñolInstitute of Biomedical Research of Barcelona, IIBB-CSIC-IDIBAPS, CIBERESP (CS), CIBERSAM (LC), 08028, Barcelona, Spain.
M MorenoDepartment of Psychology, University of Almería, CeiA3, Carretera de Sacramento s/n, 04120, Almería, Spain.
P FloresDepartment of Psychology, University of Almería, CeiA3, Carretera de Sacramento s/n, 04120, Almería, Spain. pflores@ual.es.
University of Almería · ESCentro de Investigación Biomédica en Red de Salud Mental · ESFrederiksberg Hospital · DKInstitut d'Investigacions Biomèdiques de Barcelona · ESUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleCompulsive behaviour, present in different psychiatric disorders, such as obsessive-compulsive disorder, schizophrenia and drug abuse, is associated with altered levels of monoamines, particularly serotonin (5-hydroxytryptamine) and its receptor system.

objectivesThe present study investigated whether 5-HT manipulation, through a tryptophan (TRP) depletion by diet in Wistar and Lister Hooded rats, modulates compulsive drinking in schedule-induced polydipsia (SIP) and locomotor activity in the open-field test. The levels of dopamine, noradrenaline, serotonin and its metabolite were evaluated, as well as the 5-HT

methodsWistar rats were selected as high (HD) or low (LD) drinkers according to their SIP behaviour, while Lister hooded rats did not show SIP acquisition. Both strains were fed for 14 days with either a TRP-free diet (T-) or a TRP-supplemented diet (T+)

resultsThe TRP depletion diet effectively reduced 5-HT levels in the frontal cortex, amygdala and hippocampus in both strains of rats. The TRP-depleted HD Wistar rats were more sensitive to 5-HT manipulation, exhibiting more licks on SIP than did the non-depleted HD Wistar rats, while the LD Wistar and the Lister Hooded rats did not exhibit differences in SIP. In contrast, the TRP-depleted Lister Hooded rats increased locomotor activity compared to the non-depleted rats, while no differences were found in the Wistar rats. Serotonin 2A receptor binding in the striatum was significantly reduced in the TRP-depleted HD Wistar rats.

conclusionsThese results suggest that alterations of the serotonergic system could be involved in compulsive behaviour in vulnerable populations.

Indexed as

AmygdalaAnalysis of VarianceAnimalsBehavior, AnimalBrainCompulsive BehaviorDietDisease Models, AnimalDopamineDrinkingHippocampusMaleNeostriatumPolydipsiaRatsRats, WistarDopamineReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2ASerotoninTryptophan5-HT2A bindingChronic tryptophan depletionCompulsivityInhibitory controlMonoaminesSchedule-induced polydipsia

Identifiers

PMID28280881
PMCPMC5362668
OpenAlexW2594722602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.