Evidence map›Paper›PMID 28280793›Full record

ArticleJACC. Basic to translational science2017

Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase.

Julian O M Ormerod, Jonathan D W Evans, Hussain Contractor, Matteo Beretta, Sayqa Arif, Bernadette O Fernandez, Martin Feelisch, Bernd Mayer, Rajesh K Kharbanda, Michael P Frenneaux and 1 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Ageing, sex, and cardioprotection.British journal of pharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Julian O M OrmerodOxford Heart Centre, Oxford University Hospitals, Oxford, United Kingdom.
Jonathan D W EvansDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Hussain ContractorDepartment of Cardiovascular Medicine, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Matteo BerettaDepartment of Pharmacology and Toxicology, Karl-Franzens-Universität, Graz, Austria.
Sayqa ArifDepartment of Cardiovascular Medicine, Medical School, University of Birmingham, Birmingham, United Kingdom.
Bernadette O FernandezFaculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
Martin FeelischFaculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
Bernd MayerDepartment of Pharmacology and Toxicology, Karl-Franzens-Universität, Graz, Austria.
Rajesh K KharbandaOxford Heart Centre, Oxford University Hospitals, Oxford, United Kingdom.
Michael P FrenneauxMedical School, University of East Anglia, Norwich, United Kingdom.
Houman AshrafianDepartment of Cardiovascular Medicine, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Oxford University Hospitals NHS Trust · GBUniversity of Graz · ATUniversity of Southampton · GBJohn Radcliffe Hospital · GBUniversity of Birmingham · GBUniversity of Cambridge · GBUniversity of East Anglia · GBUniversity of Oxford · GB

Funding

Medical Research Council G1001340Medical Research Council G1001536
6 · The paper itself

Abstract

Pre-conditioning is an exciting physiological phenomenon that, despite great efforts, has so far resisted translation to mainstream clinical medicine. Many potential triggers (e.g., ischemia of the organ in question or a remote organ, many different drugs) have been investigated, but recent work has implicated activation of mitochondrial aldehyde dehydrogenase (ALDH2) as central to the process. A genetic polymorphism, known as

Indexed as

Ach, acetylcholineALDH2, mitochondrial aldehyde dehydrogenasecytoprotectionendotheliumFBF, forearm blood flowFBF-R, forearm blood flow ratioGTN, glyceryl trinitrateIR, ischemia–reperfusionnitric oxidenitritereperfusion injuryRIPC, remote ischemic pre-conditioning

Identifiers

PMID28280793
PMCPMC5329169
OpenAlexW2589064973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.