ArticleACS central science2017
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry.
Article in ACS central science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Ultra-high throughput mass spectrometry with ultra high-speed separations: differential mobility spectrometry-acoustic ejection mass spectrometry (DAEMS).Bioanalysis · 2025Article
- Computational and Experimental IM-MS Determination of the Protonated Structures of Antimalarial Drugs.Journal of the American Society for Mass Spectrometry · 2024Article
- Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data.Nature communications · 2023Article
- Design of hACE2-based small peptide inhibitors against spike protein of SARS-CoV-2: a computational approach.Structural chemistry · 2023Article
- A Data-Mining Approach for the Quantitative Assessment of Physicochemical Properties of Molecular Compounds in the Skin Flux.AAPS PharmSciTech · 2021Article
- Separating chiral isomers of amphetamine and methamphetamine using chemical derivatization and differential mobility spectrometry.Analytical science advances · 2020Article
- A First Principle Model of Differential Ion Mobility: the Effect of Ion-Solvent Clustering.Journal of the American Society for Mass Spectrometry · 2019Article
- Preferential Ion Microsolvation in Mixed-Modifier Environments Observed Using Differential Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Separation of Sialylated Glycan Isomers by Differential Mobility Spectrometry.Analytical chemistry · 2019Article
- Recommendations for reporting ion mobility Mass Spectrometry measurements.Mass spectrometry reviews · 2019Review
- Determining molecular properties with differential mobility spectrometry and machine learning.Nature communications · 2018Article
- Probing the application range and selectivity of a differential mobility spectrometry-mass spectrometry platform for metabolomics.Analytical and bioanalytical chemistry · 2018Article
- Analyzing Glycopeptide Isomers by Combining Differential Mobility Spectrometry with Electron- and Collision-Based Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- From Microsolvation to Cell Permeation: Novel Separation Science for Drug Discovery.ACS central science · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong local hydrogen bonding exists between the molecule and the solvent. One method that can probe the microsolvated states of charged molecules is differential mobility spectrometry (DMS), which rapidly interrogates an ion's transitions between a solvated and desolvated state in the gas phase (i.e., few solvent molecules present). However, can the results of DMS analyses of a class of molecules reveal information about the bulk physicochemical properties of those species? Our findings presented here show that DMS behaviors correlate strongly with the measured solution phase p
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Registered trials
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