ReviewJournal of immunology research2017
Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review.
Review in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Pooled it
- The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility.Mediators of inflammation · 2018Pooled it
- Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis.BioMed research international · 2018Pooled it
- Vaginal microbiome and inflammation cytokines among Chinese women.NPJ biofilms and microbiomes · 2026Article
- Role of human papillomavirus (HPV) variants and host genetic susceptibility in cervical carcinogenesis.Archives of microbiology · 2026Review
- Efficacy of FOXP3+Treg cells combined with platelet in predicting recurrence of cervical cancer: a retrospective study.BMC women's health · 2026Article
- Ferroptosis and cellular senescence -Related Genes in Cervical Cancer: Mechanistic Insights from Multi-Omics and Clinical Sample Analysis.Translational oncology · 2025Article
- Evaluation of the Association between Genetic Polymorphism of Interleukin-1 Beta (-511C/T and +3953C/T) and Cervical Cancer Susceptibility.South Asian journal of cancer · 2025Article
- Comparison analysis of serum interleukin-6 levels and cervical cancer.Ecancermedicalscience · 2025Article
- Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study.Virology journal · 2023Article
- Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer.Theranostics · 2023Article
- Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus.Viruses · 2022Review
- Genetic Variants in Interleukin-10 Gene Association with Susceptibility and Cervical Cancer Development: A Case Control Study.Global medical genetics · 2022Article
- Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers.Microorganisms · 2021Review
- Cervical cancer in low and middle-income countries.Oncology letters · 2020Review
- Clinical significance of peripheral blood and tumor tissue lymphocyte subsets in cervical cancer patients.BMC cancer · 2020Article
- Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high-risk HPV-positive women.Cancer medicine · 2019Article
- Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells.BMC complementary and alternative medicine · 2019Article
- Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Involvement of endothelial nitric oxide synthase gene variants in the aggressiveness of uterine cervical cancer.Journal of Cancer · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (HPV) infections. Genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. We reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions with risk and progression of cervical cancer. Studies on HLA and KIR gene polymorphisms were excluded due to the abundance on literature on that subject. We show that multiple genes and loci are associated with variation in risk of cervical cancer. Rather than one single gene being responsible for cervical carcinogenesis, we postulate that variations in the different immune response genes lead to subtle differences in the effectiveness of the antiviral and antitumour immune responses, ultimately leading to differences in risk of developing cervical cancer and progressive disease after HPV infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.