Evidence map›Paper›PMID 28280525›Full record

ArticleOxidative medicine and cellular longevity2017

The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss.

Yeon-Mi Hong, Yohan Hong, Yeong-Gon Choi, Sujung Yeo, Soo Hee Jin, Sae-Won Lee, Backil Sung, Sook-Hyun Lee, Hyejin Jung, Sabina Lim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yeon-Mi HongResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Yohan HongResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Yeong-Gon ChoiResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Neurodegenerative Diseases, Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea.
Sujung YeoResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Sangji University, Wonju, Republic of Korea.ORCID 0000-0001-9883-6153
Soo Hee JinResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
Sae-Won LeeBiomedical Research Institute and IRICT, Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0002-2503-1204
Backil SungDepartment of Biology, Pacific Union College, Angwin, CA 94508, USA.
Sook-Hyun LeeResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Hyejin JungResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Sabina LimResearch Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea; Department of Meridian & Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.ORCID 0000-0003-0509-6681
Kyung Hee University · KRSeoul National University Hospital · KRHallym University · KRKyung Hee University East-West Neo Medical Center · KRPacific Union College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a previous study, we found that the short isoform of DNAJB6 (DNAJB6(S)) had been decreased in the striatum of a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). DNAJB6, one of the heat shock proteins, has been implicated in the pathogenesis of PD. In this study, we explored the cytoprotective effect of DNAJB6(S) against 1-methyl-4-phenylpyridinium ion- (MPP

Indexed as

ApoptosisCytoprotectionMembrane Potential, Mitochondrial1-Methyl-4-phenylpyridiniumbcl-2-Associated X ProteinCaspase 9Cell Line, TumorEnzyme ActivationHSP40 Heat-Shock ProteinsHumansMolecular ChaperonesNerve Tissue ProteinsProtein IsoformsReactive Oxygen SpeciesRNA, Small Interfering1-Methyl-4-phenylpyridiniumbcl-2-Associated X ProteinCaspase 9DNAJB6 protein, humanHSP40 Heat-Shock ProteinsMolecular ChaperonesNerve Tissue ProteinsProtein IsoformsReactive Oxygen SpeciesRNA, Small Interfering

Identifiers

PMID28280525
PMCPMC5322441
OpenAlexW2587352104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.