ArticleFrontiers in neurology2017
The Optic Canal: A Bottleneck for Cerebrospinal Fluid Dynamics in Normal-Tension Glaucoma?
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Morphometric Analysis of Foramina in the Middle Cranial Fossa of Dogs: A Retrospective Cone-Beam CT Study.Animals : an open access journal from MDPI · 2026Article
- Morphometric evaluation of the anatomical relationships between the superior orbital fissure and the orbital structures based on computed tomography images with clinical implications.International ophthalmology · 2024Article
- Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease.Journal of clinical medicine · 2024Review
- Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve.Fluids and barriers of the CNS · 2024Article
- Reply to Wostyn, P. Targeting the Cerebrospinal Fluid Compartment in Glaucoma: Still the Dark Side of the Moon? Comment on "Passaro et al. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle?Journal of clinical medicine · 2024Article
- Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics.Fluids and barriers of the CNS · 2022Article
- Problems in CSF and Ophthalmic Disease Research.Frontiers in ophthalmology · 2022Review
- Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study.Investigative ophthalmology & visual science · 2021Article
- Lipocalin-type Prostaglandin D Synthase Concentration Gradients in the Cerebrospinal Fluid in Normal-tension Glaucoma Patients with Optic Nerve Sheath Compartmentation.Eye and brain · 2021Article
- Normal tension glaucoma: from the brain to the eye or the inverse?Neural regeneration research · 2019Review
- A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct.Fluids and barriers of the CNS · 2019Article
- Evaluation of optic canal anatomy and symmetry using CT.BMJ open ophthalmology · 2019Article
- Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis.Eye (London, England) · 2018Review
- Perioptic Cerebrospinal Fluid Dynamics in Idiopathic Intracranial Hypertension.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases.
methodsRetrospective analysis of computed tomographic images of the cranium and orbits in 56 NTG patients (30 females and 26 males; 99 of 112 eyes; mean age 67.7 ± 11.1 years). Fifty-six age- and gender-matched subjects (mean age: 68.0 ± 11.2 years) without known ON diseases served as controls. The OCA at the orbital opening was measured in square millimeters by using the tool "freehand." Statistical analysis was performed by using the independent two-tailed
resultsThe mean orbital opening OCA in NTGs measured 14.5 ± 3.5 mm
conclusionThis study demonstrates narrower OCAs in Caucasian NTG patients compared with Caucasian control subjects without known ON diseases. Narrower OCAs might contribute to a discontinuity of the cerebrospinal fluid flow between the intracranial and orbital subarachnoid space in NTG patients. This might have an influence onto the pathophysiology in NTG.
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