Evidence map›Paper›PMID 28280407›Full record

ReviewThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2017

Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms.

Amritpal Singh Aulakh, Puneet Kaur Randhawa, Nirmal Singh, Amteshwar Singh Jaggi

Abstract readReview
In one paragraph

Review in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amritpal Singh AulakhDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala 147002, India.
Puneet Kaur RandhawaDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala 147002, India.
Nirmal SinghDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala 147002, India.
Amteshwar Singh JaggiDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala 147002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce cardioprotection. Indeed, RIPC-induced cardioprotective effects are reliant on the presence of intact neuronal pathways, which has been confirmed using nerve resection of nerves including femoral nerve, vagus nerve, and sciatic nerve. The involvement of neurogenic signaling has been further substantiated using various pharmacological modulators including hexamethonium and trimetaphan. The present review focuses on the potential involvement of neurogenic pathways in mediating remote ischemic preconditioning-induced cardioprotection.

Indexed as

CardioprotectionFemoral nerveNeurogenicRemote preconditioningSciatic nerve

Identifiers

PMID28280407
PMCPMC5343047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.