Evidence map›Paper›PMID 28280373›Full record

ArticleInfection and drug resistance2017

Effect of a small molecule Lipid II binder on bacterial cell wall stress.

Jakob Malin, Amol C Shetty, Sean C Daugherty, Erik Ph de Leeuw

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jakob MalinInstitute of Human Virology; Department of Biochemistry and Molecular Biology.
Amol C ShettyInstitute for Genome Sciences, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.
Sean C DaughertyInstitute for Genome Sciences, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.
Erik Ph de LeeuwInstitute of Human Virology; Department of Biochemistry and Molecular Biology.
Institute of Human Virology · NGUniversity of Maryland, Baltimore · US

Funding

Molecular Basis of Human Defensins as Novel Lipid II Binding Peptide AntibioticsR21AI092033 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DE LEEUW, ERIK · 2011 to 2012
$422k
NIAID NIH HHS R21 AI092033
6 · The paper itself

Abstract

We have recently identified small molecule compounds that act as binders of Lipid II, an essential precursor of bacterial cell wall biosynthesis. Lipid II comprised a hydrophilic head group that includes a peptidoglycan subunit composed of

Indexed as

antibioticsbacterial membranedefensinLipid IIvancomycin

Identifiers

PMID28280373
PMCPMC5338996
OpenAlexW2594638811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.