ArticleTherapeutics and clinical risk management2017
High expression of Aldolase A predicts poor survival in patients with clear-cell renal cell carcinoma.
Article in Therapeutics and clinical risk management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma.BMC nephrology · 2023Review
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- SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis.The FEBS journal · 2022Article
- The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis.Aging · 2022Article
- Pancreatic Ductal Adenocarcinoma Cortical Mechanics and Clinical Implications.Frontiers in oncology · 2022Review
- A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.Journal of experimental & clinical cancer research : CR · 2021Article
- Article
- High expression of aldolase A is associated with tumor progression and poor prognosis in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2021Article
- MiR-125b-2-3p associates with prognosis of ccRCC through promoting tumor metastasis via targeting EGR1.American journal of translational research · 2020Article
- Article
- Article
- The Role of HIF1-related Genes and Non-coding RNAs Expression in Clear Cell Renal Cell Carcinoma.In vivo (Athens, Greece)Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAldolase A (ALDOA) is a glycolytic enzyme that drives the glycolytic metabolic pathway in mammalian cells. The overexpression of ALDOA was observed in a variety of cancers including clear-cell renal cell carcinoma (ccRCC). However, little was known about the clinicopathological significance and prognostic value of ALDOA in ccRCC patients.
methodsThe expression of ALDOA was detected using immunohistochemical staining in 162 formalin-fixed, paraffin-embedded ccRCC sections. Prognostic outcomes correlated with ALDOA were examined using Kaplan-Meier analysis and the Cox proportional hazards model.
resultsIn patients with ccRCC, increased cytoplasmic ALDOA expression was positively associated with tumor size (
conclusionOur results suggest that ALDOA expression is an independent prognostic factor for OS in patients with ccRCC.
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