Evidence map›Paper›PMID 28280339›Full record

ArticleInternational journal of nanomedicine2017

Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer.

Hiroshi Nakase, Shinji Sakuma, Takumi Fukuchi, Takuya Yoshino, Kohta Mohri, Kohei Miyata, Hironori Kumagai, Ken-Ichiro Hiwatari, Kazufumi Tsubaki, Tetsuya Ikejima and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Hiroshi NakaseDivision of Endoscopy, Kyoto University Hospital, Kyoto, Japan; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Shinji SakumaFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Takumi FukuchiGastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan.
Takuya YoshinoDivision of Endoscopy, Kyoto University Hospital, Kyoto, Japan; Division of Inflammatory Bowel Disease, Digestive Disease Center, Kitano Hospital, Osaka, Japan.
Kohta MohriFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Kohei MiyataFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan; Advanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Hironori KumagaiAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Ken-Ichiro HiwatariAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Kazufumi TsubakiAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Tetsuya IkejimaAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Etsuo TobitaAdvanced Materials R&D Laboratory, ADEKA Corp., Tokyo, Japan.
Meiying ZhuDepartment of Radiology, Vanderbilt University Institute of Imaging Science.
Kevin J WilsonDepartment of Radiology, Vanderbilt University Institute of Imaging Science.
Kay WashingtonDivision of Gastrointestinal and Hepatic Pathology, Vanderbilt School of Medicine.
John C GoreDepartment of Radiology, Vanderbilt University Institute of Imaging Science; Department of Radiology and Radiological Sciences; Department of Biomedical Engineering; Vanderbilt Ingram Cancer Center, Vanderbilt School of Medicine; Vanderbilt Brain Institute; Molecular Physiology and Biophysics.
Wellington PhamDepartment of Radiology, Vanderbilt University Institute of Imaging Science; Department of Radiology and Radiological Sciences; Department of Biomedical Engineering; Vanderbilt Ingram Cancer Center, Vanderbilt School of Medicine; Vanderbilt Brain Institute; Molecular Physiology and Biophysics; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Setsunan University · JPVanderbilt University · USAllen Institute for Brain Science · USSaiseikai Nakatsu Hospital · JP

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Multifunctional Nanoparticles for Image-Guided Vaccine Delivery in CancerR01CA160700 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA160700NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

The Thomsen-Friedenreich (TF) antigen represents a prognostic biomarker of colorectal carcinoma. Here, using a nanobeacon, the surface of which was fabricated with peanut agglutinin as TF-binding molecules, we demonstrate that the nanobeacon is able to detect TF antigen in frozen and freshly biopsied polyps using fluorescence microscopy. Our results provide important clues about how to detect aberrant colonic tissues in the most timely fashion. Given the versatile application method for this topical nanobeacon, the protocol used in this work is amenable to clinical colonoscopy. Moreover, the prospects of clinical translation of this technology are evident.

Indexed as

AdenocarcinomaAdenomaAntigens, Tumor-Associated, CarbohydrateColorectal NeoplasmsFluorescent DyesHumansMicroscopy, FluorescenceMolecular ProbesNanoparticlesOptical ImagingPeanut AgglutininAntigens, Tumor-Associated, CarbohydrateFluorescent DyesMolecular ProbesPeanut AgglutininThomsen-Friedenreich antigencolorectal cancerfluorescence colonoscopynanobeaconTF antigen

Identifiers

PMID28280339
PMCPMC5340240
OpenAlexW2593414387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.