Trial reportInternational journal of nanomedicine2017
Proteomic analysis of tears following acupuncture treatment for menopausal dry eye disease by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry.
Trial report in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Acupuncture in the treatment of inflammation-related ocular degenerations: a systematic review.Frontiers in medicine · 2026Pooled it
- Tear Biomarkers in Alzheimer's and Parkinson's Diseases, and Multiple Sclerosis: Implications for Diagnosis (Systematic Review).International journal of molecular sciences · 2022Pooled it
- Optimizing acupuncture treatment for dry eye syndrome: a systematic review.BMC complementary and alternative medicine · 2018Pooled it
- Trial
- Laser Acupuncture Improves Tear Film Stability in Patients with Dry Eye Disease: A Two-Center Randomized-Controlled Trial.Journal of alternative and complementary medicine (New York, N.Y.) · 2021Trial
- Effect of laser acupuncture on dry eye: A study protocol for a 2-center randomized controlled trial.Medicine · 2018Trial
- From physiology to psychology: An integrative review of menopausal syndrome.World journal of psychiatry · 2025Review
- Review
- Effect of Acupuncture on Tear Proteomics in Patients with Video Display Terminal-Related Dry Eye.Journal of proteome research · 2024Article
- Treatment of Dry Eye Disease (DED) in Asia: Strategies for Short Tear Film Breakup Time-Type DED.Pharmaceutics · 2023Review
- Optimal acupuncture protocol improving symptoms of typical dry eye syndrome: meta-analysis and systematic review.Heliyon · 2023Article
- HBFP: a new repository for human body fluid proteome.Database : the journal of biological databases and curation · 2021Article
- Acupuncture for dry eye syndrome after refractive surgery: A randomized controlled pilot trial.Integrative medicine research · 2021Article
- Quantification of a panel for dry-eye protein biomarkers in tears: A comparative pilot study using standard ELISA and customized microarrays.Molecular vision · 2021Article
- Changes in Tear Proteome After Acupuncture Treatment in Dry Eye.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms.Translational vision science & technology · 2020Article
- Effect of acupuncture versus artificial tears for dry eye disease: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- Investigation of the role of herbal medicine, acupressure, and acupuncture in the menopausal symptoms: An evidence-based systematic review study.Journal of family medicine and primary care · 2020Review
- Acupoint selection for the treatment of dry eye: A systematic review and meta-analysis of randomized controlled trials.Experimental and therapeutic medicine · 2020Article
- Acupuncture for rehabilitation after surgery for cerebellopontine angle meningioma: A case report.Medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate whether acupuncture is effective at treating dry eye disease among postmenopausal women and to identify the possible mechanisms.
methodsTwenty-eight postmenopausal women with dry eye disease were randomly divided into two groups: an acupuncture plus artificial tears (AC + AT) group and an artificial tears (AT) only group. After baseline examination of clinical parameters and tear sample collection, each patient received the designated modality of topical therapy for 2 months. Post-treatment documentation of clinical parameters was recorded, and tear samples were collected. Tear samples from the AC + AT group were subjected to two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry (2D nano-LC-MS/MS). Western blot analysis was also performed on tear samples from both groups.
resultsAfter treatment, the Ocular Surface Disease Index scores, symptom assessment scores, scores of sign assessment, and tear break-up time were significantly improved in both groups (
conclusionAC + AT treatment increased protein synthesis and secretion, and improved clinical symptoms. These results indicate that acupuncture may be a complimentary therapy for treating postmenopausal dry eye disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.