Evidence map›Paper›PMID 28280324›Full record

ArticleInternational journal of nanomedicine2017

Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study.

Ting Zhang, Meng Tang, Shanshan Zhang, Yuanyuan Hu, Han Li, Tao Zhang, Yuying Xue, Yuepu Pu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ting ZhangKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Meng TangKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Shanshan ZhangKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Yuanyuan HuKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Han LiDepartment of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing, China.
Tao ZhangDepartment of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing, China.
Yuying XueKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Yuepu PuKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China.
Southeast University · CNCollaborative Innovation Center of Advanced Microstructures · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The numerous increasing use of carbon nanotubes (CNTs) derived from nanotechnology has raised concerns about their biosafety and potential toxicity. CNTs cause immunologic dysfunction and limit the application of CNTs in biomedicine. The immunological responses induced by pristine multi-walled carbon nanotubes (p-MWCNTs) and PEGylated multi-walled carbon nanotubes (MWCNTs-PEG) on BALB/c mice via an intravenous administration were investigated. The results reflect that the p-MWCNTs induced significant increases in spleen, thymus, and lung weight. Mice treated with p-MWCNTs showed altered lymphocyte populations (CD3

Indexed as

AnimalsBiphenyl CompoundsBody WeightCarbamatesCells, CulturedErythrocytesFemaleImmunoenzyme TechniquesImmunoglobulinsInflammationLungLymphocytesMiceMice, Inbred BALB CNanotechnologyNanotubes, CarbonBiphenyl CompoundsCarbamatesImmunoglobulinsNanotubes, CarbonNiacinamidePolyethylene GlycolsPristine (fungicide)PyrazolesBALB/c miceimmunosuppressionimmunotoxicitymulti-walled carbon nanotubessurface-functionalized

Identifiers

PMID28280324
PMCPMC5339008
OpenAlexW2591722967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.