Evidence map›Paper›PMID 28280323›Full record

ArticleInternational journal of nanomedicine2017

Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides.

Jiawei Sun, Lei Jiang, Yi Lin, Ethan Michael Gerhard, Xuehua Jiang, Li Li, Jian Yang, Zhongwei Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jiawei SunWest China School of Pharmacy, Sichuan University, Chengdu, Sichuan.
Lei JiangDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu.
Yi LinNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Ethan Michael GerhardDepartment of Biomedical Engineering Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA, USA.
Xuehua JiangWest China School of Pharmacy, Sichuan University, Chengdu, Sichuan.
Li LiNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Jian YangDepartment of Biomedical Engineering Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA, USA.
Zhongwei GuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Sichuan University · CNPennsylvania State University · USChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria serve as both "energy factories" and "suicide weapon stores" of cells. Targeted delivery of cytotoxic drugs to the mitochondria of tumor cells and tumor vascular cells is a promising strategy to improve the efficacy of chemotherapy. Here, multistage tumor-targeting liposomes containing two targeted peptide-modified lipids, cRGD-PEG2000-DSPE and KLA-PEG2000-DSPE, were developed for encapsulation of the anticancer drug paclitaxel (PTX, RGD-KLA/PTX-Lips). Compared with Taxol (free PTX), RGD/PTX-Lips and KLA/PTX-Lips, the half-maximal inhibitory concentration (IC

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisCaspase 3Caspase 9Cells, CulturedCytochromes cDrug Delivery SystemsFemaleHumansIntercellular Signaling Peptides and ProteinsLiposomesMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMitochondria1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)Antineoplastic Agents, PhytogenicCaspase 3Caspase 9Cytochromes cIntercellular Signaling Peptides and ProteinsKLA peptideLiposomesPaclitaxelPeptidesPhosphatidylethanolaminesPolyethylene Glycolsantiangiogenesisanticancermitochondriamultistage tumor-targeting liposomepaclitaxel

Identifiers

PMID28280323
PMCPMC5338999
OpenAlexW2593019992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.