ArticleClinical interventions in aging2017
Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Non-linear associations between UHR and bone mineral density in US adults: NHANES 2017-2018.European journal of medical research · 2025Article
- Association between serum uric acid levels and bone mineral density in Chinese and American: a cross-sectional study.Scientific reports · 2025Article
- U-Shaped association between apolipoprotein A1 and serum uric acid levels in patients with osteoporotic fractures: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Association between serum uric acid and bone mineral density in males from NHANES 2011-2020.Scientific reports · 2024Article
- Relationship between serum uric acid levels and osteoporosis.Endocrine connections · 2023Review
- Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson's disease: a cross-sectional study.Journal of bone and mineral metabolism · 2023Article
- Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Association between serum uric acid level and bone mineral density at multiple skeletal sites in middle-aged and elderly men: a cross-sectional study of a healthy population in Taiwan.Archives of osteoporosis · 2022Article
- Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort.Endocrine · 2021Article
- No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study.Scientific reports · 2021Article
- Association between the metabolome and bone mineral density in a Chinese population.EBioMedicine · 2020Article
- Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases.BMC musculoskeletal disorders · 2020Article
- Association of Serum Uric Acid Status With Bone Mineral Density in Adolescents Aged 12-19 Years.Frontiers in medicine · 2020Article
- Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition.International journal of molecular sciences · 2019Article
- Serum Uric Acid Status and Its Association with Bone Mineral Density in the Elderly People Aged 60 Years and More.International journal of endocrinology and metabolism · 2019Article
- Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sectional study from northeast China.Clinical interventions in aging · 2019Article
- Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study.Journal of bone and mineral metabolism · 2019Article
- Association of gout with osteoporotic fractures.International orthopaedics · 2018Article
- Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population.Therapeutics and clinical risk management · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age.
methodsA cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.
resultsSerum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA.
conclusionOur results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age.
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