Evidence map›Paper›PMID 28280303›Full record

ArticleDrug design, development and therapy2017

In silico discovery and in vitro activity of inhibitors against

Junie B Billones, Maria Constancia O Carrillo, Voltaire G Organo, Jamie Bernadette A Sy, Nina Abigail B Clavio, Stephani Joy Y Macalino, Inno A Emnacen, Alexandra P Lee, Paul Kenny L Ko, Gisela P Concepcion

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Drug Discovery forInternational journal of molecular sciences · 2021
    Review
  6. Article
  7. Structure-basedComputational and structural biotechnology journal · 2021
    Review
  8. The primary step of biotin synthesis in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  9. Molecules (Basel, Switzerland) · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Identification ofDrug design, development and therapy · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Junie B BillonesOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines; Institute of Pharmaceutical Sciences, National Institutes of Health, University of the Philippines Manila, Manila, Philippines.
Maria Constancia O CarrilloOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Voltaire G OrganoOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Jamie Bernadette A SyOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Nina Abigail B ClavioOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Stephani Joy Y MacalinoOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Inno A EmnacenOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Alexandra P LeeOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Paul Kenny L KoOVPAA-EIDR Program, "Computer-Aided Discovery of Compounds for the Treatment of Tuberculosis in the Philippines", Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines.
Gisela P ConcepcionMarine Science Institute, College of Science, University of the Philippines Diliman, Quezon City, Philippines.
University of the Philippines Manila · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computer-aided drug discovery and development approaches such as virtual screening, molecular docking, and in silico drug property calculations have been utilized in this effort to discover new lead compounds against tuberculosis. The enzyme 7,8-diaminopelargonic acid aminotransferase (BioA) in

Indexed as

Computer SimulationDrug DiscoveryAnti-Bacterial AgentsDose-Response Relationship, DrugEnzyme InhibitorsMicrobial Sensitivity TestsMolecular Docking SimulationMycobacterium tuberculosisStructure-Activity RelationshipTransaminases7,8-diaminoperlargonic acid aminotransferase, Mycobacterium tuberculosisAnti-Bacterial AgentsEnzyme InhibitorsTransaminasesADMETBioA inhibitorCADDDmolecular dockingpharmacophoreresazurin microtiter assaystructure-based pharmacophoreTOPKAT

Identifiers

PMID28280303
PMCPMC5338852
OpenAlexW2593014561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.