Evidence map›Paper›PMID 28280206›Full record

ArticleScience (New York, N.Y.)2017

Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning.

Mei Sheng Lau, Matthew G Schwartz, Sharmistha Kundu, Andrej J Savol, Peggy I Wang, Sharon K Marr, Daniel J Grau, Patrick Schorderet, Ruslan I Sadreyev, Clifford J Tabin and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 158 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Polycomb-mediated 3D chromatin interactions in gene regulation.Current opinion in genetics & development · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Polycomb function in early mouse development.Cell death and differentiation · 2025
    Review
  18. Review
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mei Sheng LauDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-7867-9426
Matthew G SchwartzDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9549-9868
Sharmistha KunduDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Andrej J SavolDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Peggy I WangDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1504-6370
Sharon K MarrDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Daniel J GrauDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Patrick SchorderetDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Clifford J TabinDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-2957-4871
Robert E KingstonDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. kingston@molbio.mgh.harvard.edu.ORCID 0000-0003-3628-4335
Harvard University · USMassachusetts General Hospital · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Maintenance of Gene ExpressionR01GM043901 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI KINGSTON, ROBERT · 1991 to 2018
$10.7M
Hedgehog Signaling and Organogenesis of the LimbR37HD032443 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI TABIN, CLIFFORD J. · 2005 to 2014
$5.3M
The reprogramming of limb progenitor cellsR01HD032443 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CLIFFORD J. TABIN · 1995 to 2026
$4.6M
NICHD NIH HHS R01 HD032443NICHD NIH HHS R37 HD032443NIDDK NIH HHS P30 DK040561NIGMS NIH HHS R01 GM043901
6 · The paper itself

Abstract

Nucleosomes play important structural and regulatory roles by tightly wrapping the DNA that constitutes the metazoan genome. The Polycomb group (PcG) proteins modulate nucleosomes to maintain repression of key developmental genes, including

Indexed as

Gene Expression Regulation, DevelopmentalGenes, HomeoboxGene SilencingAnimalsBody PatterningCell LineMiceMice, Mutant StrainsMutationNucleosomesPolycomb Repressive Complex 1Protein BindingSkeletonCbx2 protein, mouseNucleosomesPolycomb Repressive Complex 1

Identifiers

PMID28280206
PMCPMC5503153
OpenAlexW2595687700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.