Evidence map›Paper›PMID 28280199›Full record

ArticleScience (New York, N.Y.)2017

Design of a synthetic yeast genome.

Sarah M Richardson, Leslie A Mitchell, Giovanni Stracquadanio, Kun Yang, Jessica S Dymond, James E DiCarlo, Dongwon Lee, Cheng Lai Victor Huang, Srinivasan Chandrasegaran, Yizhi Cai and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

282 citing papers in PubMed.

  1. Review
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  12. The Kinetic Intron Hypothesis.bioRxiv : the preprint server for biology · 2026
    Article
  13. Review
  14. Review
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  18. Article
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  20. Review

222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sarah M RichardsonDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-9820-9421
Leslie A MitchellHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7869-9817
Giovanni StracquadanioDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-9819-3645
Kun YangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-1060-8082
Jessica S DymondHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2066-0861
James E DiCarloHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4728-3186
Dongwon LeeDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-1568-2249
Cheng Lai Victor HuangHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2163-6596
Srinivasan ChandrasegaranDepartment of Environmental Health Science, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Yizhi CaiHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1663-2865
Jef D BoekeHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jef.boeke@nyumc.org joel.bader@jhu.edu.ORCID 0000-0001-5322-4946
Joel S BaderDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA. jef.boeke@nyumc.org joel.bader@jhu.edu.ORCID 0000-0002-6020-4625

Funding

Biotechnology and Biological Sciences Research Council BB/M005690/1
6 · The paper itself

Abstract

We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified

Indexed as

Genome, FungalChromosomes, Artificial, YeastCodon, TerminatorDirected Molecular EvolutionGenetic EngineeringSaccharomyces cerevisiaeSynthetic BiologyCodon, Terminator

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.