ArticleScience (New York, N.Y.)2017
Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 221 citations in OpenAlex.
- Automated prototyping of genetic codes.Nature · 2026Article
- De-extinction technology and its application to conservation.The Journal of heredity · 2026Review
- Synthetic Chromosomes in Yeast: A Platform for Understanding and Programming Eukaryotic Life.Microbial biotechnology · 2026Review
- Advances in large DNA fragment assembly for microbial cell factory engineering.Quantitative biology (Beijing, China) · 2026Review
- Yeast nuclei-mediated precise delivery of synthetic megabase-scale human DNA into mammalian embryos.Nature protocols · 2026Review
- Automated linear DNA assembly of A. thaliana's chloroplast and mitochondrial genome.Nucleic acids research · 2026Article
- Synthetic rewriting technologies in mammalian cells.Nature communications · 2026Review
- De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos.Nature methods · 2025Article
- Self-authenticating genomic materials in Escherichia coli via advanced genome signatures.Communications biology · 2025Article
- The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025Review
- Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.Nature communications · 2025Article
- Towards the first synthetic eukaryotic cell.Biosafety and health · 2024Review
- The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.Nature communications · 2024Article
- Genome engineering on size reduction and complexity simplification: A review.Journal of advanced research · 2024Review
- Genome engineering on size reduction and complexity simplification: A review.Journal of advanced research · 2024Review
- Genome engineering on size reduction and complexity simplification: A review.Journal of advanced research · 2024Review
- Synthetic moss.Nature plants · 2024Article
- Genome engineering on size reduction and complexity simplification: A review.Journal of advanced research · 2024Review
- Genome engineering on size reduction and complexity simplification: A review.Journal of advanced research · 2024Review
- An Optimized Genotyping Workflow for Identifying Highly SCRaMbLEd Synthetic Yeasts.ACS synthetic biology · 2024Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
22 authors at 7 institutions in 4 countries.
Leslie A MitchellDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-7869-9817
Ann WangHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Giovanni StracquadanioHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9819-3645
Zheng KuangDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-5855-8371
Xuya WangDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.
Kun YangHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1060-8082
Sarah RichardsonHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9820-9421
J Andrew MartinDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-7867-6997
Yu ZhaoDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-4659-9832
Roy WalkerCenter for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0000-0003-0960-4591
Yisha LuoCenter for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0000-0002-4228-7527
Hongjiu DaiGenScript, Piscataway, NJ 08854, USA.
Kang DongGenScript, Piscataway, NJ 08854, USA.ORCID 0000-0003-4051-3233
Zuojian TangDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.
Yanling YangProteomics Resource Center, Office of Collaborative Science, New York University Langone School of Medicine, New York, NY 10016, USA.
Yizhi CaiCenter for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0000-0003-1663-2865
Adriana HeguyGenome Technology Center, New York University Langone School of Medicine, New York, NY 10016, USA.
Beatrix UeberheideDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-2512-0204
David FenyöDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-5049-3825
Junbiao DaiKey Laboratory for Industrial Biocatalysis (Ministry of Education), Key Laboratory of Bioinformatics (Ministry of Education), Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-5299-4700
Joel S BaderHigh Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6020-4625
Jef D BoekeDepartment of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA. jef.boeke@nyumc.org.ORCID 0000-0001-5322-4946
NYU Langone Health · USMinistry of Education of the People's Republic of China · CNUniversity of Edinburgh · GBGorgias Press (United States) · USJohns Hopkins University · USNew York Genome Center · USUniversity of Essex · GB
Funding
Biotechnology and Biological Sciences Research Council BB/M00029X/1Biotechnology and Biological Sciences Research Council BB/M005690/1Biotechnology and Biological Sciences Research Council BB/M025640/1
Abstract
We describe design, rapid assembly, and characterization of synthetic yeast Sc2.0 chromosome VI (synVI). A mitochondrial defect in the synVI strain mapped to synonymous coding changes within
Indexed as
Artificial CellsChromosomes, Artificial, YeastPhysical Chromosome MappingProteasome Endopeptidase ComplexProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSynthetic BiologyPRE4 protein, S cerevisiaeProteasome Endopeptidase ComplexSaccharomyces cerevisiae Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.