ArticleJournal of the American Society of Nephrology : JASN2017
Sickle Cell Trait and the Risk of ESRD in Blacks.
Registry-linked trialAbstract read
In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04646408 (Determinants of Cardiovascular Disease, Kidney Disease and Diabetes in People of African Ancestry With HIV), which is not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determinants of Cardiovascular Disease, Kidney Disease and Diabetes in People of African Ancestry With HIV (CKD Study)
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Chronic kidney disease in adults with sickle cell trait: a systematic review and meta-analysis.Blood advances · 2025Pooled it
- Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2022Guideline
- Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.Annals of internal medicine · 2018Pooled it
- Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.Kidney international · 2018Pooled it
- The Metabolomic Landscape of Sickle Cell Trait Nephropathy: Illuminating an Under-Recognized Problem.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Debunking myths: sickle cell trait, crises, and sudden death.Blood advances · 2025Article
- Genotype-dependent albuminuria in adult sickle cell disease in Kinshasa.Annals of hematology · 2025Article
- Addressing the pathophysiology of venous thrombosis and chronic kidney disease in sickle cell trait using a mouse model.Blood advances · 2025Article
- The Association Between Sickle Cell Anemia and Cognitive Dysfunction: A Systematic Review.Cureus · 2024Review
- APOL1 Kidney Risk Variants and Long-Term Kidney Function in Healthy Middle-Aged Black Individuals: The Atherosclerosis Risk in Communities (ARIC) Study.Kidney medicine · 2024Article
- Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Kidney involvement in hereditary transthyretin amyloidosis: a cohort study of 103 patients.Clinical kidney journal · 2022Article
- Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Review
- Prevalence and outcomes of dehydration in adults with sickle cell trait: the Atherosclerosis Risk in Communities (ARIC) study.British journal of haematology · 2022Article
- The nephropathy of sickle cell trait and sickle cell disease.Nature reviews. Nephrology · 2022Review
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- Article
- Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV.Kidney international reports · 2022Article
- Article
- Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies.Journal of human genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 1 country.
Rakhi P NaikDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; rakhi@jhmi.edu.
Marguerite R IrvinDepartments of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Suzanne JuddDepartments of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Orlando M GutiérrezDepartments of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Neil A ZakaiDepartments of Medicine and.
Vimal K DerebailDivision of Nephrology and Hypertension, Department of Medicine, University of North Carolina Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Carmen PeraltaDepartment of Medicine, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California.
Michael R LewisPathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.
Degui ZhiDepartments of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Donna ArnettCollege of Public Health, University of Kentucky, Lexington, Kentucky.
William McClellanDepartment of Epidemiology, Emory University School of Public Health, Atlanta, Georgia.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Alexander P ReinerDepartment of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
Jeffrey B KoppKidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; and.
Cheryl A WinklerBasic Research Laboratory, National Cancer Institute, Leidos Biomedical Research, Frederick National Laboratory, Frederick, Maryland.
Mary CushmanDepartments of Medicine and.
University of Alabama at Birmingham · USUniversity of Vermont · USEmory University · USJohns Hopkins University · USNational Cancer Institute · USNational Institutes of Health · USUniversity of California, San Francisco · USUniversity of Kentucky · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US
Funding
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2MFocal Segmental Glomerulosclerosis: Genetics & MechanismsZIADK043308 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$15.7MGenetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9MClinical Hematology Research Development Program (K12) at Johns HopkinsK12HL087169 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CASELLA, JAMES F · 2006 to 2016
$3.7MRegional & Racial Differences in Hemostasis & Risk of Stroke & Heart DiseaseK08HL096841 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ZAKAI, NEIL ADRIAN · 2010 to 2014
$705kSickle Cell Trait: An overlooked genetic modifier of disease in African-AmericansK08HL125100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAIK, RAKHI · 2015 to 2018
$655kAPOL1, sickle cell trait and chronic kidney disease in African AmericansR56DK104806 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA, REINER, ALEXANDER P · 2016 to 2016
$300kNHLBI NIH HHS K08 HL096841NHLBI NIH HHS K08 HL125100NHLBI NIH HHS K12 HL087169NIDDK NIH HHS R56 DK104806NIGMS NIH HHS U54 GM115428NINDS NIH HHS U01 NS041588
Abstract
Blacks, compared with whites, have an increased risk of progression to end-stage renal disease (ESRD). Emerging evidence suggests that, in addition to
Indexed as
Black PeopleApolipoprotein L1ApolipoproteinsFemaleHumansIncidenceKidney Failure, ChronicLipoproteins, HDLMaleMiddle AgedRenal Insufficiency, ChronicRisk AssessmentSickle Cell TraitAPOL1 protein, humanApolipoprotein L1ApolipoproteinsLipoproteins, HDLend stage kidney diseaseepidemiology and outcomesgenetic renal disease
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04646408ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.