Evidence map›Paper›PMID 28280002›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Mohamed A Zayed, Xiachao Wei, Kyoung-Mi Park, Larisa Belaygorod, Uzma Naim, Joseph Harvey, Li Yin, Kendall Blumer, Clay F Semenkovich

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  2. Review
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  12. The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing.Oxidative medicine and cellular longevity · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mohamed A ZayedSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; zayedm@wustl.edu.
Xiachao WeiDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kyoung-Mi ParkSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Larisa BelaygorodSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Uzma NaimSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Joseph HarveyDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Li YinDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kendall BlumerDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Clay F SemenkovichDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Center for Vascular Biology Research · USCentre de recherche Translationnelle en Médecine moléculaire · FRWashington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI James Alexander Fitzpatrick · 2013 to 2026
$27.1M
DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
DE NOVO LIPOGENESIS AND METABOLIC DISEASER01DK076729 · NIDDK · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2007 to 2015
$2.5M
MODULATING PHYSIOLOGIC EFFECTS OF PHOSPHOLIPID METABOLISM IN OBESITY AND DIABETESR01DK101392 · NIDDK · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2015 to 2019
$2.0M
THE ROLE OF PHOSPHOLIPOGENESIS IN DIABETIC PERIPHERAL ARTERIAL DISEASEK08HL132060 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2017 to 2021
$466k
NHLBI NIH HHS K08 HL132060NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK076729NIDDK NIH HHS R01 DK101392NIDDK NIH HHS T32 DK007120
6 · The paper itself

Abstract

Over 60% of lower extremity amputations are performed in patients with diabetes and peripheral arterial disease, and at least 25% require subsequent reamputation due to poor surgical site healing. The mechanisms underlying poor amputation stump healing in the setting of diabetes are not understood.

Indexed as

Amputation StumpsDiabetes Mellitus, ExperimentalAcetylcysteineAnimalsHindlimbMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesWound HealingAcetylcysteineReactive Oxygen Speciesarterial perfusionGαqNACperipheral arterial disease

Identifiers

PMID28280002
PMCPMC5434655
OpenAlexW2592566320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.