Observational studyBMJ open2017
Incidence and relative risk for developing cancer among patients with COPD: a nationwide cohort study in Taiwan.
Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Impact of chronic obstructive pulmonary disease on the prognosis of patients with extensive-stage small-cell lung cancer treated with chemoimmunotherapy.Translational lung cancer research · 2026Article
- Chronic obstructive pulmonary disease as a systemic risk factor for cancer: a nationwide cohort study in Korea.BMJ open respiratory research · 2026Article
- The Goddard score for emphysema predicts the postoperative prognosis in pancreatic cancer.Surgery today · 2026Article
- Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase.Cell death & disease · 2025Article
- Article
- Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis.Molecular cancer therapeutics · 2024Article
- Chronic Obstructive Pulmonary Disease Is Associated with Worse Oncologic Outcomes in Early-Stage Resected Pancreatic and Periampullary Cancers.Biomedicines · 2023Article
- Biological and Genetic Mechanisms of COPD, Its Diagnosis, Treatment, and Relationship with Lung Cancer.Biomedicines · 2023Review
- New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study.BMC cancer · 2022Article
- Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer.Frontiers in surgery · 2022Article
- Article
- Chronic Obstructive Pulmonary Disease Increases the Risk of Mortality among Patients with Colorectal Cancer: A Nationwide Population-Based Retrospective Cohort Study.International journal of environmental research and public health · 2021Article
- Switching of Hormone Therapies in Breast Cancer Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021Article
- Impact of tobacco-related chronic obstructive pulmonary disease on developmental trajectories of comorbidities in the Taiwan population.Scientific reports · 2020Article
- Risk of breast cancer in women with non-lactational mastitis.Scientific reports · 2019Article
- Article
- Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development.Genomics, proteomics & bioinformatics · 2018Article
- Trends in intensive care unit admissions of COPD patients from 2003 to 2013 in Taiwan.International journal of chronic obstructive pulmonary disease · 2018Article
- Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis observational study aimed to examine the incidence of malignant diseases, including specific cancer types, after the diagnosis of chronic obstructive pulmonary disease (COPD) in Taiwanese patients.
settingTaiwan's National Health Insurance Research Database.
participantsThe definition of a patient with COPD was a patient with a discharge diagnosis of COPD or at least 3 ambulatory visits for COPD. The index date was the date of the first COPD diagnosis. Patients with a history of malignancy disorders before the index date were excluded. After matching age and gender, 13 289 patients with COPD and 26 578 control participants without COPD were retrieved and analysed. They were followed from the index date to malignancy diagnosis, death or the end of study follow-up (31 December 2011), whichever came first. PRIMARY OUTCOME MEASURES: Patients were diagnosed with cancer (n=1681, 4.2%; 973 (7.3%) for patients with COPD and 728 (2.7%) for patients without COPD). The risk of 7 major cancer types, including lung, liver, colorectal, breast, prostate, stomach and oesophagus, between patients with COPD and patients without COPD was also estimated.
resultsThe mean age of all study participants was 57.9±13.5 years. The average length of follow-up to cancer incidence was 3.9 years for patients with COPD and 5.0 years for patients without COPD (p<0.01). Patients with COPD were diagnosed with cancer (n=973, 73%) at a significantly higher rate than patients without COPD (n=708, 2.7%; p<0.01). The HR for developing cancer in patients with COPD was 2.8 (95% CI 2.6 to 3.1) compared with patients without COPD after adjusting for age, sex and comorbidities. The most common cancers in patients with COPD include lung, liver, colorectal, breast, prostate and stomach cancers.
conclusionsThe risk of developing cancer is higher in patients with COPD compared with patients without COPD. Cancer screening is warranted in patients with COPD.
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