ArticleBMJ open2017
What proportion of patients with psychosis is willing to take part in research? A mental health electronic case register analysis.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04106960 (Quantitative Investigation of the Association Between the Social and Physical Features of the Environment and Participation for Those With Complex Mental Health Difficulties Living in Supported Accommodation), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Investigation of the Association Between the Social and Physical Features of the Environment and Participation for Those With Complex Mental Health Difficulties Living in Supported Accommodation
Who cites it
22 citing papers in PubMed.
- A secondary exploratory study of associations between patient- and clinician-reported clinical outcomes and fidelity for four evidence-based psychosis treatments.BMC psychiatry · 2025Trial
- Implementing physician-led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial.British journal of clinical pharmacology · 2025Trial
- Recruitment to a trial of antipsychotic reduction: impact of an acceptability study.BMC medical research methodology · 2023Trial
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- Prevalence of clinically significant radiological abnormalities in people with first episode psychosis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Ethnic disparities, clinical and pathways to care characteristics associated with the offer, uptake, and type of psychological therapy during first-episode psychosis: examining the role of early intervention for psychosis.Psychological medicine · 2025Article
- Factors that affect clinical youth engagement in digital mental health research: a qualitative sub-study nested within a prospective cohort study.BMC medical research methodology · 2025Observational
- Patient and clinician perspectives on pharmacogenetic testing for antipsychotics.Frontiers in pharmacology · 2025Article
- Observational
- Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.Schizophrenia bulletin · 2023Article
- Alterations in mental health and quality of life among healthcare workers in times of COVID-19: Four-stage cross-sectional study during first four pandemic waves in Poland.Frontiers in psychiatry · 2022Article
- Factors affecting participant recruitment and retention in borderline personality disorder research: a feasibility study.Pilot and feasibility studies · 2021Article
- The Mental Well-Being of Health Care Workers during the Peak of the COVID-19 Pandemic-A Nationwide Study in Poland.International journal of environmental research and public health · 2021Article
- Perspectives on Recruitment and Representativeness in Forensic Psychiatric Research.Frontiers in psychiatry · 2021Article
- An observational study of system-level changes to improve the recording of very brief advice for smoking cessation in an inpatient mental health setting.BMC public health · 2020Observational
- A Feasibility and Acceptability Trial of Social Cognitive Therapy in Early Psychosis Delivered Through a Virtual World: The VEEP Study.Frontiers in psychiatry · 2020Article
- Pan-London Network for Psychosis-Prevention (PNP).Frontiers in psychiatry · 2019Article
- Advances in clinical staging, early intervention, and the prevention of psychosis.F1000Research · 2019Review
- Big data: what it can and cannot achieve.BJPsych advances · 2018Article
- The Representativeness of Participants With Severe Mental Illness in a Psychosocial Clinical Trial.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe proportion of people with mental health disorders who participate in clinical research studies is much smaller than for those with physical health disorders. It is sometimes assumed that this reflects an unwillingness to volunteer for mental health research studies. We examined this issue in a large sample of patients with psychosis.
designCross-sectional study.
settingAnonymised electronic mental health record data from the South London and Maudsley NHS Foundation Trust (SLaM).
participants5787 adults diagnosed with a psychotic disorder. EXPOSURE: Whether approached prior to 1 September 2014 for consent to be approached about research participation.
main outcome measuresNumber of days spent in a psychiatric hospital, whether admitted to hospital compulsorily, and total score on the Health of the Nation Outcome Scale (HoNOS) between 1 September 2014 and 28 February 2015 with patient factors (age, gender, ethnicity, marital status and diagnosis) and treating clinical service as covariates.
results1187 patients (20.5% of the total sample) had been approached about research participation. Of those who were approached, 773 (65.1%) agreed to be contacted in future by researchers. Patients who had been approached had 2.3 fewer inpatient days (95% CI -4.4 to -0.3, p=0.03), were less likely to have had a compulsory admission (OR 0.65, 95% CI 0.50 to 0.84, p=0.001) and had a better HoNOS score (β coefficient -0.9, 95% CI -1.5 to -0.4, p=0.001) than those who had not. Among patients who were approached, there was no significant difference in clinical outcomes between those agreed to research contact and those who did not.
conclusionsAbout two-thirds of patients with psychotic disorders were willing to be contacted about participation in research. The patients who were approached had better clinical outcomes than those who were not, suggesting that clinicians were more likely to approach patients who were less unwell.
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