ArticleBiomaterials2017
Protein-free formation of bone-like apatite: New insights into the key role of carbonation.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Defect-Related Photoluminescence in Hydroxyapatite Nanoparticles Modulated by Carbonate Incorporation.ACS nanoscience Au · 2026Article
- Multi-modal comparison of murine and human incisal dentin-enamel junctions.Acta biochimica Polonica · 2025Article
- The location of cationic substitutions in carbonated biomimetic apatites significantly affects crystal nanomechanics.Scientific reports · 2024Article
- Review
- Synthesis of Biocompatible Silver-Doped Carbonate Hydroxyapatite Nanoparticles Using Microwave-Assisted Precipitation and In Vitro Studies for the Prevention of Peri-Implantitis.Journal of functional biomaterials · 2023Article
- Biomineralogical signatures of breast microcalcifications.Science advances · 2023Article
- Bone Apatite Nanocrystal: Crystalline Structure, Chemical Composition, and Architecture.Biomimetics (Basel, Switzerland) · 2023Review
- Mesoscale structural gradients in human tooth enamel.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The extracellular matrix of human bone marrow adipocytes and glucose concentration differentially alter mineralization quality without impairing osteoblastogenesis.Bone reports · 2022Article
- Mesoporous Iron(III)-Doped Hydroxyapatite Nanopowders Obtained via Iron Oxalate.Nanomaterials (Basel, Switzerland) · 2021Article
- Beyond dissolution: Xerostomia rinses affect composition and structure of biomimetic dental mineral in vitro.PloS one · 2021Article
- Characterization and Evaluation of Bone-Derived Nanoparticles as a Novel pH-Responsive Carrier for Delivery of Doxorubicin into Breast Cancer Cells.International journal of molecular sciences · 2020Article
- The role of nanoparticle structure and morphology in the dissolution kinetics and nutrient release of nitrate-doped calcium phosphate nanofertilizers.Scientific reports · 2020Article
- Chemical gradients in human enamel crystallites.Nature · 2020Article
- Micro- and Nanoparticulate Hydroxyapatite Powders as Fillers in Polyacrylate Bone Cement-A Comparative Study.Materials (Basel, Switzerland) · 2020Article
- Article
- Multiscale micromechanical modeling of the elastic properties of dentin.Journal of the mechanical behavior of biomedical materials · 2019Article
- Influences of bioapatite mineral and fibril structure on the mechanical properties of chicken bone during the laying period.Poultry science · 2019Article
- Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown.Current osteoporosis reports · 2019Review
- The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis.Acta biomaterialia · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone mechanics and physiology. However, mechanisms regulating the morphology of these mineral nanocrystals remain unclear. The dominant hypothesis attributes the size and shape regulation to organic-mineral interactions. Here, we present data supporting the hypothesis that physicochemical effects of carbonate integration within the apatite lattice control the morphology, size, and mechanics of bioapatite mineral crystals. Carbonated apatites synthesized in the absence of organic molecules presented plate-like morphologies and nanoscale crystallite dimensions. Experimentally-determined crystallite size, lattice spacing, solubility and atomic order were modified by carbonate concentration. Molecular dynamics (MD) simulations and density functional theory (DFT) calculations predicted changes in surface energy and elastic moduli with carbonate concentration. Combining these results with a scaling law predicted the experimentally observed scaling of size and energetics with carbonate concentration. The experiments and models describe a clear mechanism by which crystal dimensions are controlled by carbonate substitution. Furthermore, the results demonstrate that carbonate substitution is sufficient to drive the formation of bone-like crystallites. This new understanding points to pathways for biomimetic synthesis of novel, nanostructured biomaterials.
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