ArticleEnvironmental research2017
Tooth manganese as a biomarker of exposure and body burden in rats.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Teeth as bioarchives of metallic trace elements: a systematic review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Fetal and postnatal metal metabolism-related changes in brain function are associated with childhood behavioral deficits.Science advances · 2026Article
- Salivary Metal Ions as Potential Biomarkers for Diabetes: An Observational Study.International journal of dentistry · 2026Article
- Dentin Metal and Trace Elements in Deciduous Teeth: Findings from Project Viva.Environmental science & technology · 2025Article
- Sub-micrometer scale synchrotron x-ray fluorescence measurements of trace elements in teeth compared with laser ablation inductively coupled plasma mass spectrometry.Journal of exposure science & environmental epidemiology · 2025Article
- Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function.The Science of the total environment · 2024Article
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.Journal of clinical medicine · 2024Review
- A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023Review
- Neuroprotective Effect of Vitamin D on Behavioral and Oxidative Parameters of Male and Female Adult Wistar Rats Exposed to Mancozeb (manganese/zinc ethylene bis-dithiocarbamate).Molecular neurobiology · 2023Article
- Equine odontoclastic tooth resorption and hypercementosis (EOTRH): microspatial distribution of trace elements in hypercementosis-affected and unaffected hard dental tissues.Scientific reports · 2023Article
- Quantitative fluoride imaging of teeth using CaF emission by laser induced breakdown spectroscopy.Journal of analytical atomic spectrometry · 2023Article
- Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements.Frontiers in veterinary science · 2023Article
- Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function.Environment international · 2022Article
- Multiple metals in children's deciduous teeth: results from a community-initiated pilot study.Journal of exposure science & environmental epidemiology · 2022Article
- Bone manganese is a sensitive biomarker of ongoing elevated manganese exposure, but does not accumulate across the lifespan.Environmental research · 2022Article
- Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry.Neurotoxicology · 2021Article
- How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis.PLoS computational biology · 2020Article
- Early-life dentine manganese concentrations and intrinsic functional brain connectivity in adolescents: A pilot study.PloS one · 2019Article
- Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior.Environment international · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNeonates and children are particularly vulnerable to the toxic effects of excess manganese (Mn), but studies of Mn exposure during these developmental periods are hampered by a lack of validated biomarkers. Deciduous teeth may be used to assess Mn exposure during these developmental periods but require further validation to determine the relationship between tooth Mn, Mn in target tissues, and exposure.
objectivesTo determine the relationship of tooth Mn concentrations with: (i) exposure dose, (ii) the timing/duration of exposure, and (iii) with Mn concentrations in blood, brain and bone.
methodsRats in different treatment groups were orally exposed to 0, 25 or 50µg/g/day Mn either from postnatal day (PND) 1 - 21 and culled at PND 24, from PND 1 - 21 and culled as adults (>PND 290), or from PND 1 - throughout life and culled at >290 PND. Mn was measured in second molars, femurs, brain and blood by ICP-MS.
resultsTooth Mn increased significantly with dose in rats exposed for 21 PND and culled at 24 PND (p<0.001). In rats culled at >290 PND, tooth Mn increased with exposure duration (p<0.001) and reflected exposure duration. A significant, positive association between tooth Mn and Mn levels in blood (Spearman's rho 0.69, p<0.01) brain (rho 0.59, p<0.05) and bone (rho 0.69, p<0.01) was observed in animals with lifelong exposure. Tooth Mn and Mn levels in bone were also significantly positively associated in animals exposed only early in life (rho 0.76, p<0.001).
conclusionsTeeth are a sensitive biomarker of active and past Mn exposure and Mn burden in tissues. Unlike blood, teeth retain information on exposure history over the short and long-term.
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