ArticleEpidemics2017
Comparison and validation of two mathematical models for the impact of mass drug administration on Ascaris lumbricoides and hookworm infection.
Article in Epidemics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of mathematical models for soil-transmitted helminthiasis control strategies.PLoS neglected tropical diseases · 2026Pooled it
- Drug repurposing to combat multidrug-resistant hookworm.Biology open · 2026Article
- The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.PLoS neglected tropical diseases · 2026Article
- Optimal control strategies supported by system dynamics modelling: a study on hookworm disease in China.Infectious diseases of poverty · 2025Article
- A Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Predicting the risk and speed of drug resistance emerging in soil-transmitted helminths during preventive chemotherapy.Nature communications · 2024Article
- Fasciola spp. in Southeast Asia: a systematic review and meta-analysis protocol.Systematic reviews · 2022Article
- A prevalence-based transmission model for the study of the epidemiology and control of soil-transmitted helminthiasis.PloS one · 2022Article
- Impact of Key Assumptions About the Population Biology of Soil-Transmitted Helminths on the Sustainable Control of Morbidity.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?Parasites & vectors · 2021Article
- Impact of annual and semi-annual mass drug administration for Lymphatic Filariasis and Onchocerciasis on Hookworm Infection in Côte d'Ivoire.PLoS neglected tropical diseases · 2020Article
- Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs.The Journal of infectious diseases · 2020Article
- The impact of community-wide, mass drug administration on aggregation of soil-transmitted helminth infection in human host populations.Parasites & vectors · 2020Article
- Targeting a highly repeated germline DNA sequence for improved real-time PCR-based detection of Ascaris infection in human stool.PLoS neglected tropical diseases · 2019Article
- Sampling strategies for monitoring and evaluation of morbidity targets for soil-transmitted helminths.PLoS neglected tropical diseases · 2019Article
- Insights from quantitative analysis and mathematical modelling on the proposed WHO 2030 goals for soil-transmitted helminths.Gates open research · 2019Article
- Predicted short and long-term impact of deworming and water, hygiene, and sanitation on transmission of soil-transmitted helminths.PLoS neglected tropical diseases · 2018Article
- Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration.PLoS neglected tropical diseases · 2018Article
- The effect of assortative mixing on stability of low helminth transmission levels and on the impact of mass drug administration: Model explorations for onchocerciasis.PLoS neglected tropical diseases · 2018Article
- Counting Down the 2020 Goals for 9 Neglected Tropical Diseases: What Have We Learned From Quantitative Analysis and Transmission Modeling?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The predictions of two mathematical models of the transmission dynamics of Ascaris lumbricoides and hookworm infection and the impact of mass drug administration (MDA) are compared, using data from India. One model has an age structured partial differential equation (PDE) deterministic framework for the distribution of parasite numbers per host and sexual mating. The second model is an individual-based stochastic model. Baseline data acquired prior to treatment are used to estimate key transmission parameters, and forward projections are made, given the known MDA population coverage. Predictions are compared with observed post-treatment epidemiological patterns. The two models could equally well predict the short-term impact of deworming on A. lumbricoides and hookworm infection levels, despite being fitted to different subsets and/or summary statistics of the data. As such, the outcomes give confidence in their use as aids to policy formulation for the use of PCT to control A. lumbricoides and hookworm infection. The models further largely agree in a qualitative sense on the added benefit of semi-annual vs. annual deworming and targeting of the entire population vs. only children, as well as the potential for interruption of transmission. Further, this study also illustrates that long-term predictions are sensitive to modelling assumptions about which age groups contribute most to transmission, which depends on human demography and age-patterns in exposure and contribution to the environmental reservoir of infection, the latter being notoriously difficult to empirically quantify.
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