Trial reportThe Journal of pediatrics2017
Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.
Trial report in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00233324 (Surfactant Positive Airway Pressure and Pulse Oximetry Trial), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) in Extremely Low Birth Weight Infants
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Oxygen saturation targeting by pulse oximetry in the extremely low gestational age neonate: a quixotic quest.Current opinion in pediatrics · 2017Pooled it
- Nasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Oxygenation Instability and Short-Term Morbidities Among Very-Low-Birthweight Premature Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Effect of Intermittent Hypoxemia and Hyperoxemia during the Neonatal Period on Control of Breathing Function among Infants Born Extremely Preterm.The Journal of pediatrics · 2025Observational
- Tachycardia-Desaturation Episodes in Neonatal Intensive Care Unit Patients with and without Bronchopulmonary Dysplasia.American journal of perinatology · 2025Article
- Impact of cessation of caffeine citrate therapy on intermittent hypoxemia patterns among preterm infants born before 34 weeks.Frontiers in pediatrics · 2025Article
- Neonatal outcomes of preterm infants with pulmonary hypertension: clustering based on prenatal risk factors.Pediatric research · 2024Article
- Maturation of cardioventilatory physiological trajectories in extremely preterm infants.Pediatric research · 2024Article
- Predicting Pulmonary Outcomes in Extremely Preterm Infants from Recordings of Cardiorespiratory Data: A Question of Chicken and Egg.American journal of respiratory and critical care medicine · 2023Article
- Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.American journal of respiratory and critical care medicine · 2023Article
- Automated Oxygen Delivery in Neonatal Intensive Care.Frontiers in pediatrics · 2022Review
- The relationship between intermittent hypoxemia events and neural outcomes in neonates.Experimental neurology · 2021Review
- Improving VLBW infant outcomes with big data analytics.Pediatric research · 2021Article
- Optimisation of clinical workflow and monitor settings safely reduces alarms in the NICU.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.Neonatology · 2020Article
- Moderate hyperoxia induces senescence in developing human lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Intermittent Hypoxemia in Preterm Infants.Clinics in perinatology · 2019Review
- Intermittent hypoxemia and oxidative stress in preterm infants.Respiratory physiology & neurobiology · 2019Review
- Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity.JAMA ophthalmology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial. STUDY
designMedian oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5 minutes) were documented in 1054 infants of 24
resultsLower target infants who were small for gestational age had the lowest oxygen saturation and highest incidence of intermittent hypoxemia during the first 3 days of life. The lowest quartile of oxygen saturation (≤92%) during the first 3 days of life was associated with lower 90-day survival for both infants born appropriate and SGA. An increased incidence of intermittent hypoxemia events during the first 3 days of life was associated with lower 90-day survival only in infants born SGA.
conclusionLower achieved oxygen saturation during the first 3 days of life was associated with lower 90-day survival in extremely preterm infants. Infants born SGA had enhanced vulnerability to lower oxygen saturation targets as evidenced by lower achieved oxygen saturation and an association between increased intermittent hypoxemia events and lower survival.
trial registrationClinicalTrials.gov: NCT00233324.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.