ArticleAtherosclerosis2017
Dense calcium and lesion-specific ischemia: A comparison of CCTA with fractional flow reserve.
Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 10 citations in OpenAlex.
- Coronary CT Angiography-Based Prediction Model for Hemodynamically Significant Coronary Stenosis Integrating Morphological and Plaque Characteristics.Cardiovascular engineering and technology · 2026Article
- Association between myocardial ischemia and plaque characteristics in chronic total occlusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics.Journal of clinical medicine · 2020Review
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6 authors at 3 institutions in 1 country.
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Abstract
BACKGROUND AND
aimsStudies evaluating the relationship between dense coronary calcium (DC) and myocardial ischemia have had incongruent results. We sought to clarify whether DC, as detected by computed coronary tomographic angiography (CCTA), is an independent predictor of ischemia as measured by invasive fractional flow reserve (FFR).
methodsIn total, 249 (399 lesions) stable patients undergoing CCTA and invasive FFR were enrolled for this post-hoc analysis. DC was defined as plaque with ≥350 HU using quantification software, and ischemia was defined as FFR ≤0.80. We evaluated the relationship of dense calcium volume (DCV), lesion plaque volume (LPV), non-calcified plaque volume (NCV), and area stenosis (AS) with ischemia using logistic regression reporting odds ratios (OR) with 95% confidence intervals (95% CI).
resultsMean age was 63.0 ± 8.6 years, and 73 (29.3%) were female. Mean DCV was higher in lesions with FFR ≤0.80 (57.0 ± 54.7 mm
conclusionsDense calcium is not an independent predictor of ischemia, but rather a marker of aggregate LPV, which in turn, is predictive of ischemia.
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