ArticleNeuron2017
Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.
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Who cites it
164 citing papers in PubMed, 390 citations in OpenAlex.
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions.eLife · 2026Article
- Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology.Cell reports · 2026Article
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- Microglia-specific NLRP3 inhibition mitigates hippocampal neuroinflammation and cognitive deficits after hemorrhagic shock with resuscitation.Behavioral and brain functions : BBF · 2026Article
- Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Spectral dependence as a framework for neural coordination.Current research in neurobiology · 2026Article
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Human hippocampal theta-gamma coupling coordinates sequential planning during navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lost in Space and Thought: Navigating the Cognitive Map in Alzheimer's Disease.Neuroscience bulletin · 2026Review
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Exercise enhances hippocampal-cortical ripple interactions in the human brain.Brain communications · 2026Article
- Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.Neuron · 2025Article
- Theta-nested gamma oscillations balance prediction and vigilance in spatial navigation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sensorimotor Theta Oscillations Coordinate Speech Movements.bioRxiv : the preprint server for biology · 2025Article
- Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.Nature neuroscience · 2025Article
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
104 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Theta-gamma phase coupling and spike timing within theta oscillations are prominent features of the hippocampus and are often related to navigation and memory. However, the mechanisms that give rise to these relationships are not well understood. Using high spatial resolution electrophysiology, we investigated the influence of CA3 and entorhinal inputs on the timing of CA1 neurons. The theta-phase preference and excitatory strength of the afferent CA3 and entorhinal inputs effectively timed the principal neuron activity, as well as regulated distinct CA1 interneuron populations in multiple tasks and behavioral states. Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input at place field entry, coupled with feedback depression of proximal dendritic and perisomatic inhibition, allowing the CA3 input to gain control toward the exit. Thus, upstream inputs interact with local mechanisms to determine theta-phase timing of hippocampal neurons to support memory and spatial navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.