Evidence map›Paper›PMID 28279354›Full record

ArticleNeuron2017

GARLH Family Proteins Stabilize GABA

Tokiwa Yamasaki, Erika Hoyos-Ramirez, James S Martenson, Megumi Morimoto-Tomita, Susumu Tomita

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 134 citations in OpenAlex.

  1. GABASynapse (New York, N.Y.) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  7. Review
  8. Review
  9. Resolving native GABANature · 2025
    Article
  10. Article
  11. Article
  12. Haploinsufficiency of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. GABAFrontiers in cellular neuroscience · 2024
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tokiwa YamasakiDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Erika Hoyos-RamirezDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
James S MartensonDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Megumi Morimoto-TomitaDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Susumu TomitaDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susumu.tomita@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
UC Davis/NIH NeuroMab FacilityU24NS050606 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI TRIMMER, JAMES S · 2005 to 2014
$15.6M
Identify functional modulators of ionotropic neurotransmitter receptors in brainU01MH104984 · NIMH · YALE UNIVERSITY · PI TOMITA, SUSUMU · 2014 to 2016
$1.0M
Molecular mechanism for the synaptic localization of GABA(A)Rs.F30MH099742 · NIMH · YALE UNIVERSITY · PI MARTENSON, JAMES · 2013 to 2014
$73k
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM007205NIMH NIH HHS F30 MH099742NIMH NIH HHS U01 MH104984NINDS NIH HHS U24 NS050606
6 · The paper itself

Abstract

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by ionotropic GABA

Indexed as

AnimalsCells, CulturedHippocampusHumansMice, Inbred C57BLMice, TransgenicNeurotransmitter AgentsProtein SubunitsReceptors, GABA-ASynapsesSynaptic TransmissionNeurotransmitter AgentsProtein SubunitsReceptors, GABA-A

Identifiers

PMID28279354
PMCPMC5347473
OpenAlexW2592656674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.