ArticleCell host & microbe2017
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.
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Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
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Who cites it
70 citing papers in PubMed.
- Host andGut microbes · 2026Article
- EradicatingBioactive materials · 2026Article
- Internalization ofAnnals of medicine · 2026Review
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- Characteristics and Incidence of Gastric Cancer Among Patients with Autoimmune and Non-autoimmune Atrophic Gastritis in a U.S. Population.Digestive diseases and sciences · 2026Article
- A vicious cycle inducer in gastric pathogenesis: implication of Helicobacter pylori.Archives of microbiology · 2026Review
- Pathogenicity and virulence ofVirulence · 2025Review
- Article
- Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori.Biology open · 2025Article
- Consumption patterns of the frequently used drugs and their impact on the gastric cancer epidemiological indices in Ukraine, 2014-2021.Przeglad gastroenterologiczny · 2025Article
- Functional and intricate interaction network connectingmicroLife · 2025Article
- Molecular insights into the fine-tuning of pH-dependent ArsR-mediated regulation of the SabA adhesin in Helicobacter pylori.Nucleic acids research · 2024Article
- Review
- Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA.Cell communication and signaling : CCS · 2024Review
- Changes in the tissue elements of the gastric mucosa interacting with different strains ofBioscience of microbiota, food and health · 2024Article
- Pivotal role ofFrontiers in medicine · 2024Review
- Gastric cancer in Ukraine: epidemiologic data and its nosological structure between 2003 and 2020.Przeglad gastroenterologiczny · 2024Article
- Diversification and deleterious role of microbiome in gastric cancer.Cancer reports (Hoboken, N.J.) · 2023Review
- Transcriptional analysis of Helicobacter pylori cytotoxic-associated gene-pathogenicity island in response to different pH levels and proton pump inhibitor exposure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Biofilm and Cancer: Interactions and Future Directions for Cancer Therapy.International journal of molecular sciences · 2023Review
10 more citing papers are in PubMed but not listed here.
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Authors and funding
61 authors.
Jeanna A BugaytsovaDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Oscar BjörnhamDepartment of Applied Physics and Electronics, Umeå University, 901 87 Umeå, Sweden.
Yevgen A ChernovDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Pär GideonssonDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Sara HenrikssonDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Melissa MendezDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Rolf SjöströmDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Jafar MahdaviDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden; School of Life Sciences, CBS, University of Nottingham, NG7 2RD Nottingham, UK.
Anna ShevtsovaDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Dag IlverDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Kristof MoonensStructural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Macarena P Quintana-HayashiDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Roman MoskalenkoDepartment of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
Christopher AisenbreyDepartment of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Göran BylundDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Alexej SchmidtDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Anna ÅbergDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Kristoffer BrännströmDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Verena KönigerMax von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany.
Susanne VikströmDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Lena RakhimovaDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden; Department of Medical Biosciences, Umeå University, 901 85 Umeå, Sweden.
Anders HoferDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Johan ÖgrenDepartment of Odontology, Umeå University, 901 87 Umeå, Sweden.
Hui LiuDepartment of Medicine, USUHS, Bethesda, MD 20814, USA.
Matthew D GoldmanDepartment of Pediatrics, USUHS, Bethesda, MD 20814, USA.
Jeannette M WhitmireDepartment of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA.
Jörgen ÅdénDepartment of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Justine YounsonKing's College London, Dental Institute, London SE1 9RT, UK.
Charles G KellyKing's College London, Dental Institute, London SE1 9RT, UK.
Robert H GilmanDepartment of International Health, John Hopkins School of Public Health, Baltimore, MD 21205, USA.
Abhijit ChowdhuryCentre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education & Research, Kolkata 700020, India.
Asish K MukhopadhyayDivision of Bacteriology, National Institute of Cholera and Enteric Diseases P33, CIT Road, Kolkata 700010, India.
G Balakrish NairTranslational Health Science and Technology Institute 496, Phase-III, Udyog Vihar Gurgaon, 122016 Haryana, India.
Konstantinos S PapadakosHellenic Pasteur Institute, Athens 11521, Greece.
Beatriz Martinez-GonzalezHellenic Pasteur Institute, Athens 11521, Greece.
Dionyssios N SgourasHellenic Pasteur Institute, Athens 11521, Greece.
Lars EngstrandDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Magnus UnemoDepartment of Laboratory Medicine, Microbiology, Örebro University Hospital, 701 85 Örebro, Sweden.
Dan DanielssonDepartment of Laboratory Medicine, Microbiology, Örebro University Hospital, 701 85 Örebro, Sweden.
Sebastian SuerbaumMax von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig Site, 30625 Hannover, Germany; German Center for Infection Research (DZIF), Munich Site, 80336 Munich, Germany.
Stefan OscarsonCentre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Ludmilla A Morozova-RocheDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Anders OlofssonDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Gerhard GröbnerDepartment of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Jan HolgerssonDepartment of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
Anders EsbergDepartment of Odontology, Umeå University, 901 87 Umeå, Sweden.
Nicklas StrömbergDepartment of Odontology, Umeå University, 901 87 Umeå, Sweden.
Maréne LandströmDepartment of Medical Biosciences, Umeå University, 901 85 Umeå, Sweden.
Angela M EldridgeDepartment of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Brett A ChromyDepartment of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Lori M HansenDepartments of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA.
Jay V SolnickDepartments of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA; California National Primate Research Center, University of California Davis School of Medicine, Davis, CA 95616, USA.
Sara K LindénDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Rainer HaasMax von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany; German Center for Infection Research (DZIF), Munich Site, 80336 Munich, Germany.
Andre DuboisDepartment of Medicine, USUHS, Bethesda, MD 20814, USA.
D Scott MerrellDepartment of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA.
Staffan SchedinDepartment of Applied Physics and Electronics, Umeå University, 901 87 Umeå, Sweden.
Han RemautStructural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Anna ArnqvistDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Douglas E BergDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Thomas BorénDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden. Electronic address: thomas.boren@umu.se.
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MBACTERIAL &CHEMICAL CARCINOGENS IN GASTRIC ONCOGENESISR01CA082312 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MERRELL, D. SCOTT · 2000 to 2012
$4.0MModulation of Outer Membrane Protein Expressin in Helicobacter pyloriR01AI070803 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2008 to 2012
$2.4MH.PYLORI POPULATION GENETICS AND GENOME EVOLUTIONR01DK063041 · NIDDK · WASHINGTON UNIVERSITY · PI BERG, DOUGLAS EUGENE · 2003 to 2007
$1.6MRole of H. pylori Outer Membrane Proteins in Colonization and Host ResponseR01AI081037 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLNICK, JAY V. · 2009 to 2013
$1.1MNCI NIH HHS R01 CA082312NIAID NIH HHS R01 AI070803NIAID NIH HHS R01 AI081037NIDDK NIH HHS R01 DK063041NIH HHS P51 OD011107
Abstract
The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.
Indexed as
Bacterial AdhesionAdhesins, BacterialGastric MucosaHelicobacter InfectionsHelicobacter pyloriHydrogen-Ion ConcentrationAdhesins, BacterialBabA protein, Helicobacter pyloriacid responsivenessadaptationblood group antigen-binding adhesiondiversitygastric aciditygastric cancerHelicobacter pylorimultimerizationpolymorphismsubpopulations
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