Evidence map›Paper›PMID 28279265›Full record

ArticleBiomaterials2017

Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.

Vladimíra Moulisová, Cristina Gonzalez-García, Marco Cantini, Aleixandre Rodrigo-Navarro, Jessica Weaver, Mercedes Costell, Roser Sabater I Serra, Matthew J Dalby, Andrés J García, Manuel Salmerón-Sánchez

Open access · hybridAbstract read
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 73 citations in OpenAlex.

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  9. Recent advances in 3D models of tumor invasion.Current opinion in biomedical engineering · 2021
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  20. Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Vladimíra MoulisováDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, United Kingdom.
Cristina Gonzalez-GarcíaDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, United Kingdom.
Marco CantiniDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, United Kingdom.
Aleixandre Rodrigo-NavarroDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, United Kingdom.
Jessica WeaverWoodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mercedes CostellDepartament de Bioquimica i Biologia Molecular, Universitat de València, Burjassot, Spain.
Roser Sabater I SerraCentre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia, Spain.
Matthew J DalbyCentre for Cell Engineering, Institute of Molecular Cell and Systems Biology, University of Glasgow, Joseph Black Bld, University Avenue, Glasgow G12 8QQ, United Kingdom.
Andrés J GarcíaWoodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Manuel Salmerón-SánchezDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, United Kingdom. Electronic address: Manuel.Salmeron-Sanchez@glasgow.ac.uk.
University of Glasgow · GBGeorgia Institute of Technology · USUniversitat de València · ESUniversitat Politècnica de València · ES

Funding

Hydrogels for hMSC delivery & engraftmentR01AR062368 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2022
$3.5M
Osseo-reparative, integrin-specific materialsR01AR062920 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2021
$3.2M
Medical Research Council MR/L022710/1NIAMS NIH HHS R01 AR062368NIAMS NIH HHS R01 AR062920
6 · The paper itself

Abstract

We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into nanonetworks which provide availability of critical binding domains. Importantly, the growth factor binding (FNIII

Indexed as

Cellular MicroenvironmentNeovascularization, PhysiologicSignal TransductionAnimalsExtracellular Signal-Regulated MAP KinasesFibronectinsFocal Adhesion Protein-Tyrosine KinasesHumansHuman Umbilical Vein Endothelial CellsImage Processing, Computer-AssistedIntegrinsMaleMice, Inbred C57BLMutationPhospholipase C gammaPhosphorylationExtracellular Signal-Regulated MAP KinasesFibronectinsFocal Adhesion Protein-Tyrosine KinasesIntegrinsPhospholipase C gammaVascular Endothelial Growth Factor AFibronectinGrowth factorspoly(ethyl acrylate)Protein assemblyVascularizationVEGF

Identifiers

PMID28279265
PMCPMC5354119
OpenAlexW2590515065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.